Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 1/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.41 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.35 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | GLS | O94925 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL8553524 | 0.87 | POLB (0.40) | MEN1KMT2ALMNAPOLB | |
| Hydrochloric Acid SCHEMBL8626224 | 0.86 | DGAT1 (0.39) | FFAR4PPARDMEN1KMT2AFFAR1 | |
| Hydrochloric Acid SCHEMBL8626219 | 0.76 | ALDH1A1 (0.38) | ITGB3ITGA2BFFAR4MEN1KMT2A | |
| Bromide SCHEMBL8552783 | 0.75 | POLB (0.42) | MEN1KMT2ALMNAPOLB | |
| Bromide SCHEMBL8625322 | 0.71 | HCRTR1 (0.43) | ITGB3ITGA2BFFAR4PPARDMEN1 | |
| SCHEMBL8625987 | 0.69 | HCRTR1 (0.43) | ITGB3ITGA2BFFAR4PPARDMEN1 | |
| Bromide SCHEMBL8554224 | 0.69 | MAPT (0.50) | MEN1KMT2ANPC1POLBRAB9A | |
| Water SCHEMBL8628635 | 0.69 | HCRTR1 (0.43) | ITGB3ITGA2BFFAR4PPARDMEN1 | |
| SCHEMBL8554053 | 0.67 | MAPT (0.51) | MEN1KMT2ANPC1POLBRAB9A | |
| SCHEMBL8325106 | 0.67 | ITGB3 (0.55) | ITGB3ITGA2BAOC3PPARDPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5817677-A | ANTITHROMBOSIS AGENTS | DR. KARL THOMAE GMBH (DE) | 1998-10-06 | — | — | US | disclosed |