Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 7/20 | 0.33 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.41 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.41 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1316129 | 0.97 | PABPC1 (0.43) | PABPC1APOBEC3AEIF4HAPOBEC3GCYP2D6 | |
| Bromide SCHEMBL8598361 | 0.90 | MEN1 (0.47) | CYP2D6MAPTCYP2C9MEN1TP53 | |
| SCHEMBL1316266 | 0.88 | MEN1 (0.48) | CYP2D6MAPTCYP2C9MEN1TP53 | |
| Iodide SCHEMBL5014654 | 0.87 | HTT (0.50) | CYP2D6MAPTCYP2C9MEN1TP53 | |
| SCHEMBL14364681 | 0.79 | SMN1; SMN2 (0.50) | CYP2D6MAPTCYP2C9MEN1CYP1A2 | |
| Bromide SCHEMBL5707663 | 0.78 | KMT2A (0.60) | PABPC1APOBEC3AEIF4HAPOBEC3GCYP2D6 | |
| SCHEMBL18588440 | 0.77 | MAPT (0.56) | PABPC1APOBEC3AEIF4HAPOBEC3GCYP2D6 | |
| SCHEMBL19892478 | 0.77 | MAPT (0.52) | PABPC1APOBEC3AEIF4HAPOBEC3GCYP2D6 | |
| Bromide SCHEMBL4769564 | 0.76 | KMT2A (0.72) | CYP2D6MAPTCYP2C9MEN1TP53 | |
| Bromide SCHEMBL28044241 | 0.76 | KMT2A (0.72) | CYP2D6MAPTCYP2C9MEN1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5818636-A | Complementary surface confined polmer electrochromic materials, systems, and methods of fabrication therefor | MOLECULAR DISPLAYS, INC. (US) | 1998-10-06 | — | — | US | claimed |
| US-5818636-A | Complementary surface confined polmer electrochromic materials, systems, and methods of fabrication therefor | MOLECULAR DISPLAYS, INC. (US) | 1998-10-06 | — | — | US | disclosed |