Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.40 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8618406 | 0.86 | LTA4H (0.50) | HRH3ALDH1A1LMNAMEN1USP2 | |
| SCHEMBL9633219 | 0.82 | TRPV1 (0.34) | ALDH1A1LMNACYP3A4CASP1PPARG | |
| SCHEMBL8623162 | 0.79 | LMNA (0.64) | LMNAFFAR1L3MBTL1PPARGPPARA | |
| SCHEMBL11452565 | 0.77 | NQO1 (0.56) | ALDH1A1LMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL9130547 | 0.75 | TRPV1 (0.39) | MEN1CYP3A4KMT2APPARGPPARA | |
| SCHEMBL9130559 | 0.75 | TRPV1 (0.39) | MEN1CYP3A4KMT2APPARGPPARA | |
| SCHEMBL7625466 | 0.74 | MEN1 (0.59) | ALDH1A1LMNAMEN1USP2CYP3A4 | |
| SCHEMBL8420664 | 0.74 | KCNA3 (0.59) | FFAR1L3MBTL1PPARGS1PR1 | |
| SCHEMBL25194799 | 0.73 | LMNA (0.51) | ALDH1A1LMNAMEN1CYP3A4KMT2A | |
| SCHEMBL23358307 | 0.73 | HRH3 (0.49) | HRH3FFAR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5712396-A | PHOSPHONOSULFONATE COMPOUNDS USED FOR INHIBITING CHOLESTEROL BIOSYNTHESIS AND ATHEROSCLEROSIS | MAGNIN DAVID R (US) | 1998-01-27 | — | — | US | disclosed |
| US-5567841-A | ANTICHOLESTEROL AGENT | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-10-22 | — | — | US | disclosed |
| US-5470845-A | Methods of using α-phosphonosulfonate squalene synthetase inhibitors including the treatment of atherosclerosis and hypercholesterolemia | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-11-28 | — | — | US | disclosed |