Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 9/20 | 0.54 |
| ▸ | GRIK2 | Q13002 | 9/20 | 0.54 |
| ▸ | GRIK5 | Q16478 | 8/20 | 0.54 |
| ▸ | GRIA1 | P42261 | 8/20 | 0.54 |
| ▸ | GRIA2 | P42262 | 8/20 | 0.54 |
| ▸ | GRIA3 | P42263 | 8/20 | 0.54 |
| ▸ | GRIA4 | P48058 | 8/20 | 0.54 |
| ▸ | GRIK3 | Q13003 | 8/20 | 0.54 |
| ▸ | GRIK4 | Q16099 | 3/20 | 0.54 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.48 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.48 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.43 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.43 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.43 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.43 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8618714 | 0.83 | GRIA1 (0.44) | GRIK1GRIK2GRIK5GRIA1GRIA2 | |
| SCHEMBL8618891 | 0.81 | GRIK1 (0.57) | GRIK1GRIK2GRIK5GRIA1GRIA2 | |
| Bicarbonate SCHEMBL8807164 | 0.81 | SIRT2 (0.47) | GRIK1GRIK2GRIK5GRIK3GRIK4 | |
| SCHEMBL8620601 | 0.80 | SIRT2 (0.43) | GRIK1GRIK2GRIK5GRIA1GRIA2 | |
| SCHEMBL9749646 | 0.79 | KDM4E (0.45) | SIRT2PARP1 | |
| SCHEMBL8621736 | 0.77 | SIRT2 (0.43) | GRIK1GRIK2GRIK5GRIA1GRIA2 | |
| SCHEMBL8616658 | 0.76 | SIRT2 (0.40) | GRIK1GRIK2GRIK5GRIA1GRIA2 | |
| SCHEMBL8610724 | 0.75 | FDPS (0.48) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL8807743 | 0.75 | SIRT2 (0.41) | GRIK1GRIK2GRIK5GRIA1GRIA2 | |
| SCHEMBL4704743 | 0.73 | GRIA1 (0.47) | GRIK1GRIK2GRIK5GRIA1GRIA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5710138-A | Benzo f!quinoxalinedione derivatives, their production and use in pharmaceutical agents | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-01-20 | — | — | US | claimed |
| EP-0696289-B1 | BENZO[F]QUINOXALINDIONE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN DRUGS | SCHERING AG (DE) | 1997-03-12 | — | — | EP | claimed |
| US-5710138-A | Benzo f!quinoxalinedione derivatives, their production and use in pharmaceutical agents | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-01-20 | — | — | US | disclosed |