Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EYA3 | Q99504 | 4/20 | 0.56 |
| ▸ | SLC22A12 | Q96S37 | 8/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | TTR | P02766 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | EYA2 | O00167 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.43 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ALB | P02768 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8623751 | 0.88 | HTT (0.51) | EYA3LMNAHTTCA12CA9 | |
| SCHEMBL8624371 | 0.86 | HTT (0.63) | EYA3SLC22A12LMNAHTTCA12 | |
| SCHEMBL8619761 | 0.82 | PTPN1 (0.42) | EYA3SLC22A12LMNAHTTCA12 | |
| SCHEMBL8617571 | 0.80 | HTT (0.64) | SLC22A12LMNAHTTCA12CA9 | |
| SCHEMBL15698033 | 0.80 | EYA3 (0.83) | EYA3SLC22A12LMNACYP2C19TTR | |
| SCHEMBL8619555 | 0.79 | TTR (0.69) | EYA3SLC22A12LMNAHTTCA12 | |
| SCHEMBL8617962 | 0.76 | THRA (0.52) | EYA3LMNAHTTCA12CA9 | |
| SCHEMBL20702018 | 0.74 | EYA3 (0.59) | EYA3SLC22A12LMNAHTTCYP2C19 | |
| SCHEMBL20702027 | 0.74 | EYA3 (0.72) | EYA3SLC22A12LMNAHTTCYP2C19 | |
| SCHEMBL25815049 | 0.73 | SLC22A12 (0.71) | EYA3SLC22A12LMNACYP2C19TTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5854282-A | 3-benzoyl benzofuran derivatives as thyroid hormone antagonists | KARO BIO AB (SE) | 1998-12-29 | — | — | US | disclosed |
| EP-0775129-B1 | 3-BENZOYL BENZOFURAN DERIVATIVES AS THYROID HORMONE ANTAGONISTS | KAROBIO AB (SE) | 1998-10-21 | — | — | EP | disclosed |