Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 4/20 | 0.52 |
| ▸ | THRB | P10828 | 4/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | KDM5A | P29375 | 6/20 | 0.35 |
| ▸ | KDM4A | O75164 | 3/20 | 0.35 |
| ▸ | ING2 | Q9H160 | 1/20 | 0.35 |
| ▸ | SIRT3 | Q9NTG7 | 3/20 | 0.35 |
| ▸ | EYA3 | Q99504 | 1/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8619949 | 0.88 | THRA (0.45) | THRATHRBHTTLMNAMAPK1 | |
| SCHEMBL8623751 | 0.85 | HTT (0.51) | HTTLMNAMAPK1TDP1L3MBTL1 | |
| SCHEMBL8619759 | 0.79 | HTT (0.35) | THRATHRBHTTLMNAMAPK1 | |
| SCHEMBL8763724 | 0.78 | THRA (0.49) | THRATHRBCYP2C9KDM5AKDM4A | |
| SCHEMBL8624371 | 0.77 | HTT (0.63) | HTTLMNAMAPK1TDP1L3MBTL1 | |
| SCHEMBL8624230 | 0.77 | THRA (0.48) | THRATHRBMAPK1TDP1L3MBTL1 | |
| SCHEMBL8617561 | 0.76 | THRB (0.47) | THRATHRBHTTLMNANPC1 | |
| SCHEMBL8623723 | 0.76 | EYA3 (0.56) | THRBHTTLMNAMAPK1TDP1 | |
| SCHEMBL8617571 | 0.76 | HTT (0.64) | HTTLMNAMAPK1TDP1L3MBTL1 | |
| SCHEMBL8619761 | 0.75 | PTPN1 (0.42) | HTTLMNAMAPK1TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5854282-A | 3-benzoyl benzofuran derivatives as thyroid hormone antagonists | KARO BIO AB (SE) | 1998-12-29 | — | — | US | disclosed |
| EP-0775129-B1 | 3-BENZOYL BENZOFURAN DERIVATIVES AS THYROID HORMONE ANTAGONISTS | KAROBIO AB (SE) | 1998-10-21 | — | — | EP | disclosed |
| EP-0775129-A1 | 3-BENZOYL BENZOFURAN DERIVATIVES AS THYROID HORMONE ANTAGONISTS | KARO BIO AB (SE) | 1997-05-28 | — | — | EP | disclosed |
| WO-1996005190-A1 | 3-BENZOYL BENZOFURAN DERIVATIVES AS THYROID HORMONE ANTAGONISTS | KARO BIO AB (SE) | 1996-02-22 | — | — | WO | disclosed |