Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | CA12 | O43570 | 2/20 | 0.51 |
| ▸ | CA9 | Q16790 | 2/20 | 0.51 |
| ▸ | EYA3 | Q99504 | 6/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.42 |
| ▸ | TTR | P02766 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8623723 | 0.88 | EYA3 (0.56) | HTTLMNACA12CA9EYA3 | |
| SCHEMBL8624371 | 0.87 | HTT (0.63) | HTTLMNACA12CA9EYA3 | |
| SCHEMBL8617962 | 0.85 | THRA (0.52) | HTTLMNACA12CA9EYA3 | |
| SCHEMBL8617571 | 0.81 | HTT (0.64) | HTTLMNACA12CA9CYP2C19 | |
| SCHEMBL8618726 | 0.78 | EYA3 (0.68) | HTTLMNAEYA3MAPK1TDP1 | |
| SCHEMBL8619761 | 0.74 | PTPN1 (0.42) | HTTLMNACA12CA9EYA3 | |
| SCHEMBL8619949 | 0.74 | THRA (0.45) | HTTLMNAMAPK1TDP1L3MBTL1 | |
| SCHEMBL9486241 | 0.72 | HTT (0.86) | HTTLMNACA12CA9EYA3 | |
| SCHEMBL9485478 | 0.72 | ESR1 (0.51) | ABCB11PGRHTR1AADRA2ADRD1 | |
| SCHEMBL3969280 | 0.71 | HTT (0.60) | HTTLMNACA12CA9MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5854282-A | 3-benzoyl benzofuran derivatives as thyroid hormone antagonists | KARO BIO AB (SE) | 1998-12-29 | — | — | US | disclosed |
| EP-0775129-B1 | 3-BENZOYL BENZOFURAN DERIVATIVES AS THYROID HORMONE ANTAGONISTS | KAROBIO AB (SE) | 1998-10-21 | — | — | EP | disclosed |