Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE1 | P42892 | 3/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | HTRA1 | Q92743 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8762388 | 0.86 | ECE1 (0.62) | ECE1 | |
| SCHEMBL8761340 | 0.82 | ECE1 (0.47) | ECE1HTRA1ALDH1A1 | |
| SCHEMBL8763057 | 0.78 | LMNA (0.43) | HTRA1 | |
| SCHEMBL8762379 | 0.78 | SMN1; SMN2 (0.41) | ECE1HTRA1ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL8624813 | 0.76 | SMN1; SMN2 (0.48) | ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL8762494 | 0.76 | L3MBTL1 (0.50) | ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL8628000 | 0.75 | HPGD (0.49) | ALDH1A1POLBSMN1; SMN2MEN1KMT2A | |
| SCHEMBL8762413 | 0.74 | MAPK1 (0.45) | ALDH1A1POLB | |
| SCHEMBL8627352 | 0.72 | EPHX1 (0.34) | ECE1EPHX1 | |
| SCHEMBL7432362 | 0.68 | EPHX1 (0.38) | EPHX1ALDH1A1POLBSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636142-B1 | LACTAM PEPTIDES HAVING HLE INHIBITING ACTIVITY | ZENECA LTD (GB) | 1998-06-17 | — | — | EP | claimed |
| EP-0636141-B1 | PYRIMIDINYL ACETAMIDES AS ELASTASE INHIBITORS | ZENECA LTD (GB) | 1997-06-25 | — | — | EP | claimed |
| EP-0636142-B1 | LACTAM PEPTIDES HAVING HLE INHIBITING ACTIVITY | ZENECA LTD (GB) | 1998-06-17 | — | — | EP | disclosed |
| EP-0636141-B1 | PYRIMIDINYL ACETAMIDES AS ELASTASE INHIBITORS | ZENECA LTD (GB) | 1997-06-25 | — | — | EP | disclosed |