Citric Acid

Citric Acid

SCHEMBL8626229

CC(O)CO.O=C(O)CC(O)(CC(=O)O)C(=O)O.O=C(O)CC(O)(CC(=O)O)C(=O)O.O=C(O)CC(O)(CC(=O)O)C(=O)O

nearest known ligand 0.65

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2

The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 known ✓ O00255 1/20 0.37
ALDH1A1 P00352 2/20 0.65
TDP1 Q9NUW8 1/20 0.43
KDM4E B2RXH2 3/20 0.42
TSHR P16473 2/20 0.42
MAPT P10636 2/20 0.42
LMNA P02545 2/20 0.42
ALOX15 P16050 1/20 0.42
CPT2 P23786 1/20 0.42
ACLY P53396 1/20 0.42
HMGCR P04035 1/20 0.41
CHRM1 P11229 1/20 0.41
TBXA2R P21731 1/20 0.41
ADRA1A P35348 1/20 0.41
CYP2D6 P10635 2/20 0.39
CYP2C19 P33261 1/20 0.39
HIF1A Q16665 1/20 0.39
SLC13A5 Q86YT5 4/20 0.38
CYP1A2 P05177 1/20 0.37
KMT2A Q03164 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Citric Acid SCHEMBL428394 1.00 ALDH1A1 (0.65) ALDH1A1TDP1KDM4ETSHRMAPT
Citric Acid SCHEMBL11971644 1.00 ALDH1A1 (0.65) ALDH1A1TDP1KDM4ETSHRMAPT
Citric Acid SCHEMBL489814 1.00 ALDH1A1 (0.65) ALDH1A1TDP1KDM4ETSHRMAPT
Citric Acid SCHEMBL21874899 0.96 ALDH1A1 (0.60) ALDH1A1TDP1KDM4ETSHRMAPT
Citric Acid SCHEMBL1498084 0.89 ALDH1A1 (0.68) ALDH1A1KDM4ETSHRMAPTLMNA
Citric Acid SCHEMBL536573 0.89 ALDH1A1 (0.68) ALDH1A1KDM4ETSHRMAPTLMNA
Citric Acid SCHEMBL28560793 0.89 ALDH1A1 (0.75) ALDH1A1KDM4ETSHRMAPTLMNA
Citric Acid SCHEMBL2199115 0.89 ALDH1A1 (0.75) ALDH1A1KDM4ETSHRMAPTLMNA
Citric Acid SCHEMBL425247 0.87 ALDH1A1 (0.65) ALDH1A1KDM4ETSHRMAPTLMNA
Citric Acid SCHEMBL426131 0.86 ALDH1A1 (0.71) ALDH1A1KDM4ETSHRMAPTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114805928-B Biological base plasticizer for metaphenylene 江苏森禾化工科技有限公司 2023-10-03 CN claimed
EP-0680747-B1 Cosmetic and/or dermatologic composition containing a glycerol tri(alpha-hydroxyacylate) as sole precursor of glycerol OREAL (FR) 1998-07-01 EP claimed
US-5560904-A MOISTURIZER OR SOFTENER CAPABLE OF RELEASING GLYCEROL AND HYDROXY ACID ON SKIN VIA ENZYMATIC REACTION L'OREAL (FR) 1996-10-01 US claimed
CN-117897058-A Collagen compositions and methods of use thereof 现代牧场股份有限公司 2024-04-16 CN disclosed
US-20240099955-A1 SKINCARE COMPOSITIONS AND METHODS OF USE THEREOF HTL BIOTECHNOLOGY INNOVATION INC. 2024-03-28 US disclosed
EP-4329521-A2 COLLAGEN COMPOSITIONS AND METHODS OF USE THEREOF Modern Meadow, Inc. (US) 2024-03-06 EP disclosed
US-11896694-B2 Compositions for removing nail polish L'OREAL (FR) 2024-02-13 US disclosed
EP-4288084-A1 SKINCARE COMPOSITIONS AND METHODS OF USE THEREOF Modern Meadow, Inc. (US) 2023-12-13 EP disclosed
WO-2023235775-A2 COLLAGEN COMPOSITIONS AND METHODS OF USE THEREOF MODERN MEADOW, INC. (US) 2023-12-07 WO disclosed
CN-116847871-A Skin care compositions and methods of use 现代牧场股份有限公司 2023-10-03 CN disclosed
CN-114805928-B Biological base plasticizer for metaphenylene 江苏森禾化工科技有限公司 2023-10-03 CN disclosed
CN-114805928-B Biological base plasticizer for metaphenylene 江苏森禾化工科技有限公司 2023-10-03 CN disclosed
WO-2022026085-A1 GEL COMPOSITIONS COMPRISING HYDROPHOBIC SILICA AND A COPOLYMER FORMED FROM SULFONIC ACID ACRYLIC MONOMER L'OREAL (FR) 2022-02-03 WO disclosed
US-20220031580-A1 GEL COMPOSITIONS COMPRISING HYDROPHOBIC SILICA AND A COPOLYMER FORMED FROM SULFONIC ACID ACRYLIC MONOMER L'OREAL (FR) 2022-02-03 US disclosed
US-20210121377-A1 COMPOSITIONS FOR REMOVING NAIL POLISH L'OREAL (FR) 2021-04-29 US disclosed
US-10912724-B2 Compositions for removing nail polish L'OREAL (FR) 2021-02-09 US disclosed
EP-3716938-A1 COMPOSITIONS FOR REMOVING NAIL POLISH L'OREAL (FR) 2020-10-07 EP disclosed
US-20200069544-A1 COMPOSITIONS FOR REMOVING NAIL POLISH L'OREAL (FR) 2020-03-05 US disclosed
US-5560904-A MOISTURIZER OR SOFTENER CAPABLE OF RELEASING GLYCEROL AND HYDROXY ACID ON SKIN VIA ENZYMATIC REACTION L'OREAL (FR) 1996-10-01 US disclosed