Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | CPT2 | P23786 | 1/20 | 0.42 |
| ▸ | ACLY | P53396 | 1/20 | 0.42 |
| ▸ | HMGCR | P04035 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | SLC13A5 | Q86YT5 | 4/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL428394 | 1.00 | ALDH1A1 (0.65) | ALDH1A1TDP1KDM4ETSHRMAPT | |
| Citric Acid SCHEMBL11971644 | 1.00 | ALDH1A1 (0.65) | ALDH1A1TDP1KDM4ETSHRMAPT | |
| Citric Acid SCHEMBL8626229 | 1.00 | ALDH1A1 (0.65) | ALDH1A1TDP1KDM4ETSHRMAPT | |
| Citric Acid SCHEMBL21874899 | 0.96 | ALDH1A1 (0.60) | ALDH1A1TDP1KDM4ETSHRMAPT | |
| Citric Acid SCHEMBL1498084 | 0.89 | ALDH1A1 (0.68) | ALDH1A1KDM4ETSHRMAPTLMNA | |
| Citric Acid SCHEMBL536573 | 0.89 | ALDH1A1 (0.68) | ALDH1A1KDM4ETSHRMAPTLMNA | |
| Citric Acid SCHEMBL28560793 | 0.89 | ALDH1A1 (0.75) | ALDH1A1KDM4ETSHRMAPTLMNA | |
| Citric Acid SCHEMBL2199115 | 0.89 | ALDH1A1 (0.75) | ALDH1A1KDM4ETSHRMAPTLMNA | |
| Citric Acid SCHEMBL425247 | 0.87 | ALDH1A1 (0.65) | ALDH1A1KDM4ETSHRMAPTLMNA | |
| Citric Acid SCHEMBL426131 | 0.86 | ALDH1A1 (0.71) | ALDH1A1KDM4ETSHRMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 256 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12350365-B2 | Products and methods for reducing malodor from the pudendum | WELLS FARGO BANK, N.A. | 2025-07-08 | — | — | US | claimed |
| CN-118388942-A | Preparation method of PLA-based biodegradable composite material | 沈阳化工大学 | 2024-07-26 | — | — | CN | claimed |
| CN-118006096-A | Preparation method of PLA/PCL-based biodegradable modified material | 沈阳化工大学 | 2024-05-10 | — | — | CN | claimed |
| CN-117568377-A | Recombinant propylene glycol-free citrate bacillus for constitutive expression of dsRNA and application thereof | 上海交通大学 | 2024-02-20 | — | — | CN | claimed |
| CN-117304665-A | Preparation method of polylactic acid grafted copolymer and bio-based auxiliary agent synergistically modified PLA/PBAT composite material | 沈阳化工大学 | 2023-12-29 | — | — | CN | claimed |
| CN-116706072-A | Binder composition for secondary battery electrode, slurry composition, electrode, and secondary battery | 上海百公里新材料科技有限公司 | 2023-09-05 | — | — | CN | claimed |
| CN-116075497-A | Composite forms of tetraacetylethylene diamine | 一星解决方案有限公司 | 2023-05-05 | — | — | CN | claimed |
| CN-115006269-A | Washing-discharging two-in-one composition and application thereof | 凡可化妆品研究开发(广州)有限公司 | 2022-09-06 | — | — | CN | claimed |
| CN-113693993-A | Foot beautifying cream and preparation method thereof | 江西广恩和药业股份有限公司 | 2021-11-26 | — | — | CN | claimed |
| CN-111467299-A | Multi-repair intensive water replenishing hyaluronic acid stock solution and preparation method thereof | 广州协和生物医药科技有限公司 | 2020-07-31 | — | — | CN | claimed |
| US-20050058693-A1 | Tissue products comprising a moisturizing and lubricating composition | KIMBERLY-CLARK WORLDWIDE, INC. | 2005-03-17 | — | — | US | claimed |
| EP-1455722-A1 | SYSTEM FOR SKIN HEALTH OF ABSORBENT ARTICLE WEARERS | Kimberly-Clark Worldwide, Inc. (US) | 2004-09-15 | — | — | EP | claimed |
| WO-2004022116-A1 | INTERLABIAL PAD MOISTURIZING AND LUBRICATING COMPOSITION | KIMBERLY-CLARK WORLDWIDE, INC. (US) | 2004-03-18 | — | — | WO | claimed |
| WO-2004022117-A1 | MOISTURIZING AND LUBRICATING COMPOSITION | KIMBERLY-CLARK WORLDWIDE, INC. (US) | 2004-03-18 | — | — | WO | claimed |
| WO-2004022115-A1 | ABSORBENT PRODUCT MOISTURIZING AND LUBRICATING COMPOSITION | KIMBERLY-CLARK WORLDWIDE, INC. (US) | 2004-03-18 | — | — | WO | claimed |
| WO-2003057122-A1 | SYSTEM FOR SKIN HEALTH OF ABSORBENT ARTICLE WEARERS | KIMBERLY-CLARK WORLDWIDE INC. (US) | 2003-07-17 | — | — | WO | claimed |
| US-20030130636-A1 | System for improving skin health of absorbent article wearers | KIMBERLY-CLARK WORLDWIDE, INC. | 2003-07-10 | — | — | US | claimed |
| EP-0182659-B1 | SHAPED HYDROGEL ARTICLES | JOHNSON & JOHNSON VISION PRODUCTS, INC. (US) | 1993-05-05 | — | — | EP | claimed |
| US-4680336-A | SOFT CONTACT LENSES, DILUENTS | VISTAKON, INC. (US) | 1987-07-14 | — | — | US | claimed |
| EP-0182659-A2 | Shaped hydrogel articles | JOHNSON & JOHNSON VISION PRODUCTS, INC. (US) | 1986-05-28 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050058693-A1 | Tissue products comprising a moisturizing and lubricating composition | MUC1, CUTA, COL14A1 | MEN1 2672/4885ALDH1A1 467/4885TDP1 225/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.