Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.38 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.38 |
| ▸ | KDM2A | Q9Y2K7 | 5/20 | 0.37 |
| ▸ | TET2 | Q6N021 | 3/20 | 0.37 |
| ▸ | KDM4A | O75164 | 2/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.37 |
| ▸ | TET3 | O43151 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.36 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | KDM5C | P41229 | 3/20 | 0.35 |
| ▸ | PHF8 | Q9UPP1 | 3/20 | 0.35 |
| ▸ | GABRP | O00591 | 2/20 | 0.35 |
| ▸ | GABRD | O14764 | 2/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diethanolamine SCHEMBL1832717 | 0.91 | TP53 (0.55) | TP53CYP1A2ALDH1A1KDM4EMEN1 | |
| Diethanolamine SCHEMBL2803527 | 0.89 | TP53 (0.52) | TP53CYP1A2ALDH1A1KDM4EMEN1 | |
| Diethanolamine SCHEMBL1266494 | 0.89 | TP53 (0.52) | TP53CYP1A2ALDH1A1KDM4EMEN1 | |
| Succinic Acid SCHEMBL1832868 | 0.84 | EGLN1 (0.53) | EGLN1LMNAALKBH5SUCNR1KDM2A | |
| Succinic Acid SCHEMBL18492331 | 0.84 | EGLN1 (0.53) | EGLN1LMNAALKBH5SUCNR1KDM2A | |
| Succinic Acid SCHEMBL935212 | 0.82 | TP53 (0.69) | TP53CYP1A2EGLN1LMNAALKBH5 | |
| Succinic Acid SCHEMBL15949792 | 0.82 | TP53 (0.69) | TP53CYP1A2EGLN1LMNAALKBH5 | |
| Succinic Acid SCHEMBL194813 | 0.80 | GPR84 (0.54) | TP53CYP1A2EGLN1LMNAALKBH5 | |
| Lactic Acid SCHEMBL21356987 | 0.80 | TP53 (0.58) | TP53CYP1A2EGLN1LMNAALKBH5 | |
| Diethanolamine SCHEMBL8859117 | 0.80 | ALDH1A1 (0.37) | TP53ALDH1A1KDM4EMEN1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5712232-A | ANIONIC SURFACTANT AND A SALT | KAO CORPORATION (JP) | 1998-01-27 | — | — | US | disclosed |