Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | IDH1 | O75874 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6875807 | 0.89 | MAPT (0.39) | POLBMAPTGAAL3MBTL1SMN1; SMN2 | |
| SCHEMBL10404091 | 0.89 | ALDH1A1 (0.37) | POLBALDH1A1MAPTCTSSNPC1 | |
| SCHEMBL10546411 | 0.89 | KMT2A (0.41) | POLBNPC1GAAMEN1KMT2A | |
| SCHEMBL10540280 | 0.88 | POLB (0.39) | POLBALDH1A1GAAL3MBTL1CNR1 | |
| SCHEMBL10541118 | 0.88 | PKM (0.39) | POLBALDH1A1MEN1CNR1CNR2 | |
| SCHEMBL10543451 | 0.87 | SMN1; SMN2 (0.34) | POLBMAPTGAAL3MBTL1SMN1; SMN2 | |
| SCHEMBL10546806 | 0.87 | HTT (0.43) | ALDH1A1CTSSNPC1L3MBTL1MEN1 | |
| SCHEMBL10543056 | 0.87 | ACACB (0.41) | ALDH1A1NPC1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL10541152 | 0.87 | CTSL (0.41) | POLBALDH1A1MAPTL3MBTL1MEN1 | |
| SCHEMBL10547320 | 0.87 | PKM (0.41) | ALDH1A1MAPTMEN1CNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4244951-A | Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide | PFIZER INC. (US) | 1981-01-13 | — | — | US | claimed |
| EP-0503597-B1 | Penam derivatives and processes for producing the same | OTSUKA KAGAKU KK (JP) | 1998-06-10 | — | — | EP | disclosed |
| US-5599925-A | BACTERICIDES | OTSUKA KAGAKU KABUSHIKI KAISHA (JP) | 1997-02-04 | — | — | US | disclosed |
| EP-0280240-B1 | Cephalosporin derivatives, process for their preparation and antibacterial agents | BANYU PHARMA CO LTD (JP) | 1994-09-14 | — | — | EP | disclosed |
| EP-0225634-B1 | Antibacterial compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1994-04-06 | — | — | EP | disclosed |
| US-5300497-A | Broad spectrum antibiotics and bactericides; stable to beta-lactamase; effective against antibiotic-resistant bacteria | TOYAMA CHEMICAL CO., LTD. (JP) | 1994-04-05 | — | — | US | disclosed |
| CN-1021910-C | LANKACIDIN DERIVATIVES AND PRODUCTION THEREOF | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1993-08-25 | — | — | CN | disclosed |
| US-5185330-A | Penicillins/ad/ | TOYAMA CHEMICAL CO., LTD. (JP) | 1993-02-09 | — | — | US | disclosed |
| EP-0503597-A2 | Penam derivatives and processes for producing the same | OTSUKA KAGAKU KABUSHIKI KAISHA (JP) | 1992-09-16 | — | — | EP | disclosed |
| US-5049665-A | Cephalosporin derivatives | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1991-09-17 | — | — | US | disclosed |
| EP-0160252-A2 | Antibacterial compounds | Takeda Chemical Industries, Ltd. (JP) | 1985-11-06 | — | — | EP | disclosed |
| EP-0135683-A1 | Method for production of cephalosporin compounds | Takeda Chemical Industries, Ltd. (JP) | 1985-04-03 | — | — | EP | disclosed |
| US-4488994-A | Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide | PFIZER INC. (US) | 1984-12-18 | — | — | US | disclosed |
| US-4432903-A | Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide | PFIZER INC. (US) | 1984-02-21 | — | — | US | disclosed |
| US-4419284-A | Preparation of halomethyl esters (and related esters) of penicillanic acid 1,1-dioxide | PFIZER INC. (US) | 1983-12-06 | — | — | US | disclosed |
| EP-0093376-A2 | 1-Sulfo-2-azetidinone derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1983-11-09 | — | — | EP | disclosed |
| EP-0074611-A2 | Method for production of cephalosporin compounds | Takeda Chemical Industries, Ltd. (JP) | 1983-03-23 | — | — | EP | disclosed |
| US-4377524-A | Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide | PFIZER INC. (US) | 1983-03-22 | — | — | US | disclosed |
| EP-0061315-A1 | Process for preparing penicillanic acid 1,1-dioxide derivatives and certain intermediates useful therein | PFIZER INC. (US) | 1982-09-29 | — | — | EP | disclosed |
| US-4244951-A | Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide | PFIZER INC. (US) | 1981-01-13 | — | — | US | disclosed |