Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.37 |
| ▸ | MELK | Q14680 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | DPP4 | P27487 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | PRNP | P04156 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | MMP12 | P39900 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5160632 | 0.78 | ALDH1A1 (0.46) | EGLN1MELKALDH1A1HSD17B10KDM4E | |
| SCHEMBL28824630 | 0.72 | LMNA (0.38) | LMNAMEN1KMT2APOLBPARP1 | |
| SCHEMBL29467245 | 0.72 | LMNA (0.38) | LMNAMEN1KMT2APOLBPARP1 | |
| SCHEMBL8627135 | 0.72 | MELK (0.37) | MEN1KMT2AMELKPARP1ALDH1A1 | |
| SCHEMBL10967425 | 0.65 | PDE3B (0.44) | EGLN1PARP1 | |
| SCHEMBL10054252 | 0.64 | ALDH1A1 (0.38) | EGLN1MELKALDH1A1HSD17B10 | |
| SCHEMBL12446804 | 0.64 | LMNA (0.53) | LMNAMEN1KMT2APOLBPARP1 | |
| SCHEMBL9374144 | 0.63 | LMNA (0.64) | LMNAMEN1KMT2APOLBALDH1A1 | |
| Benzimidazole SCHEMBL4324024 | 0.62 | ALDH1A1 (0.66) | PARP1ALDH1A1MAPTHPGDHTT | |
| SCHEMBL18909186 | 0.61 | ALDH1A1 (0.46) | LMNAALDH1A1MAPTHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10550130-B2 | Benzo-thiazolo-imidazole compounds and uses thereof | KING FAISAL SPECIALIST HOSPITAL & RESEARCH CENTRE (SA) | 2020-02-04 | — | — | US | claimed |
| EP-3070092-B1 | 3-PHENYL-THIAZOLO[3,2-A]BENZIMIDAZOLE DERIVATIVES AS ALDEHYDE DEHYDROGENASE 1 (ALDH-1) MODULATORS FOR THE TREATMENT OF BREAST CANCER OR LEUKEMIA, AND FOR MANIPULATING CULTURED ALDH-1 POSITIVE BREAST CANCER OR LEUKEMIA CELLS | UNIV KING SAUD (SA) | 2018-11-07 | — | — | EP | claimed |
| US-20160272652-A1 | BENZO-THIAZOLO-IMIDAZOLE COMPOUNDS AND USES THEREOF | KING SAUD UNIVERSITY (SA) | 2016-09-22 | — | — | US | claimed |
| EP-3070092-A1 | 3-PHENYL-THIAZOLO[3,2-A]BENZIMIDAZOLE DERIVATIVES FOR THE TREATMENT OF CANCER AND FOR THE MANIPULATION OF CULTURED ALDEHYDE DEHYDROGENASE 1 (ALDH-1) POSITIVE CANCER CELLS | King Saud University (SA) | 2016-09-21 | — | — | EP | claimed |
| US-10550130-B2 | Benzo-thiazolo-imidazole compounds and uses thereof | KING FAISAL SPECIALIST HOSPITAL & RESEARCH CENTRE (SA) | 2020-02-04 | — | — | US | disclosed |
| US-10550130-B2 | Benzo-thiazolo-imidazole compounds and uses thereof | KING FAISAL SPECIALIST HOSPITAL & RESEARCH CENTRE (SA) | 2020-02-04 | — | — | US | disclosed |
| US-10550130-B2 | Benzo-thiazolo-imidazole compounds and uses thereof | KING FAISAL SPECIALIST HOSPITAL & RESEARCH CENTRE (SA) | 2020-02-04 | — | — | US | disclosed |
| EP-3070092-B1 | 3-PHENYL-THIAZOLO[3,2-A]BENZIMIDAZOLE DERIVATIVES AS ALDEHYDE DEHYDROGENASE 1 (ALDH-1) MODULATORS FOR THE TREATMENT OF BREAST CANCER OR LEUKEMIA, AND FOR MANIPULATING CULTURED ALDH-1 POSITIVE BREAST CANCER OR LEUKEMIA CELLS | UNIV KING SAUD (SA) | 2018-11-07 | — | — | EP | disclosed |
| US-20160272652-A1 | BENZO-THIAZOLO-IMIDAZOLE COMPOUNDS AND USES THEREOF | KING SAUD UNIVERSITY (SA) | 2016-09-22 | — | — | US | disclosed |
| US-20160272652-A1 | BENZO-THIAZOLO-IMIDAZOLE COMPOUNDS AND USES THEREOF | KING SAUD UNIVERSITY (SA) | 2016-09-22 | — | — | US | disclosed |
| EP-3070092-A1 | 3-PHENYL-THIAZOLO[3,2-A]BENZIMIDAZOLE DERIVATIVES FOR THE TREATMENT OF CANCER AND FOR THE MANIPULATION OF CULTURED ALDEHYDE DEHYDROGENASE 1 (ALDH-1) POSITIVE CANCER CELLS | King Saud University (SA) | 2016-09-21 | — | — | EP | disclosed |
| EP-3070092-A1 | 3-PHENYL-THIAZOLO[3,2-A]BENZIMIDAZOLE DERIVATIVES FOR THE TREATMENT OF CANCER AND FOR THE MANIPULATION OF CULTURED ALDEHYDE DEHYDROGENASE 1 (ALDH-1) POSITIVE CANCER CELLS | King Saud University (SA) | 2016-09-21 | — | — | EP | disclosed |
| EP-0843681-A1 | HETEROCYCLE-FUSED THIAZOLE DERIVATIVES | YUNGJIN PHARMACEUTICAL CO., LTD. (KR) | 1998-05-27 | — | — | EP | disclosed |
| WO-1997003076-A1 | HETEROCYCLE-FUSED THIAZOLE DERIVATIVES | YUNGJIN PHARMACEUTICAL CO., LTD. (KR) | 1997-01-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160272652-A1 | BENZO-THIAZOLO-IMIDAZOLE COMPOUNDS AND USES THEREOF | BRD4, TEC, BTK | LMNA 3782/4885MEN1 1431/4885KMT2A 2916/4885 |
| US-10550130-B2 | Benzo-thiazolo-imidazole compounds and uses thereof | TP53, THPO, TBCA | LMNA 2160/4885MEN1 582/4885KMT2A 2821/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.