Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | P2RX3 | P56373 | 4/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 2/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8630031 | 0.88 | PTGS2 (0.41) | PTGS2PTGS1CA12CA2CA9 | |
| SCHEMBL8629321 | 0.88 | PTGS2 (0.59) | PTGS2PTGS1 | |
| SCHEMBL8628069 | 0.86 | F10 (0.35) | PTGS2PTGS1F10PTGES2 | |
| SCHEMBL7780829 | 0.85 | PTGS2 (0.62) | PTGS2PTGS1CA12CA2CA9 | |
| SCHEMBL8632812 | 0.83 | ALOX5AP (0.47) | PTGS2PTGS1F10 | |
| SCHEMBL8632216 | 0.82 | SCN9A (0.46) | F10F2 | |
| SCHEMBL8632840 | 0.82 | LRRK2 (0.42) | PTGS2PTGS1CA12CA2CA9 | |
| SCHEMBL8631346 | 0.81 | NPC1 (0.40) | CA2PTGES2 | |
| SCHEMBL8627632 | 0.79 | CA1 (0.42) | CA12CA2CA9CA4 | |
| SCHEMBL8632289 | 0.79 | AKR1B1 (0.40) | PTGS2CA12CA2CA9CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |