Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 2/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8631047 | 0.87 | ALOX5AP (0.42) | F10PTGS1PTGS2PTGES2 | |
| SCHEMBL8631176 | 0.87 | PTGS2 (0.46) | PTGS1PTGS2PTGES2 | |
| SCHEMBL8627772 | 0.86 | PTGS2 (0.47) | F10PTGS1PTGS2PTGES2 | |
| SCHEMBL8630031 | 0.85 | PTGS2 (0.41) | F10PTGS1PTGS2LRRK2 | |
| SCHEMBL7780130 | 0.83 | CA12 (0.47) | PTGS1PTGS2LRRK2 | |
| SCHEMBL8658511 | 0.82 | PTGS2 (0.40) | F10PTGS1PTGS2PTGES2 | |
| SCHEMBL8632216 | 0.81 | SCN9A (0.46) | F10TP53MAPT | |
| SCHEMBL8632840 | 0.81 | LRRK2 (0.42) | F10PTGS1PTGS2LRRK2 | |
| SCHEMBL8627632 | 0.81 | CA1 (0.42) | LRRK2MAPT | |
| SCHEMBL8632289 | 0.81 | AKR1B1 (0.40) | F10PTGS2LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |