Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HTRA1 | Q92743 | 2/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MLYCD | O95822 | 2/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8762379 | 0.88 | SMN1; SMN2 (0.41) | NPC1RAB9AALDH1A1HTRA1MMP8 | |
| SCHEMBL8624813 | 0.86 | SMN1; SMN2 (0.48) | ALDH1A1MEN1KMT2A | |
| SCHEMBL8762494 | 0.84 | L3MBTL1 (0.50) | NPC1RAB9AALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL8762388 | 0.80 | ECE1 (0.62) | — | |
| SCHEMBL8625002 | 0.79 | ECE1 (0.43) | ALDH1A1HTRA1MEN1KMT2APOLB | |
| SCHEMBL8625810 | 0.78 | POLB (0.44) | OPRK1NPC1RAB9AALDH1A1CYP1A2 | |
| SCHEMBL8628000 | 0.77 | HPGD (0.49) | ALDH1A1MEN1TSHRKMT2APOLB | |
| SCHEMBL8761340 | 0.77 | ECE1 (0.47) | ALDH1A1HTRA1MAPT | |
| SCHEMBL21959109 | 0.74 | POLB (0.48) | OPRK1NPC1RAB9AALDH1A1CYP1A2 | |
| SCHEMBL18228853 | 0.74 | POLB (0.48) | OPRK1NPC1RAB9AALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636141-B1 | PYRIMIDINYL ACETAMIDES AS ELASTASE INHIBITORS | ZENECA LTD (GB) | 1997-06-25 | — | — | EP | claimed |
| EP-0636142-B1 | LACTAM PEPTIDES HAVING HLE INHIBITING ACTIVITY | ZENECA LTD (GB) | 1998-06-17 | — | — | EP | disclosed |
| EP-0636141-B1 | PYRIMIDINYL ACETAMIDES AS ELASTASE INHIBITORS | ZENECA LTD (GB) | 1997-06-25 | — | — | EP | disclosed |