Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.58 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.56 |
| ▸ | STAT3 | P40763 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.54 |
| ▸ | NCOR2 | Q9Y618 | 4/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.52 |
| ▸ | TUBB | P07437 | 1/20 | 0.52 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.52 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.52 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.52 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.52 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.52 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.52 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.52 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.52 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8666558 | 0.87 | SMN1; SMN2 (0.61) | FFAR4KEAP1TSHRHDAC3NCOR2 | |
| SCHEMBL8627623 | 0.85 | F10 (0.64) | KEAP1STAT3HDAC3NCOR2HDAC2 | |
| SCHEMBL8622517 | 0.82 | FFAR4 (0.55) | FFAR4KEAP1TSHRALDH1A1KDM4E | |
| SCHEMBL7249253 | 0.80 | F10 (0.69) | HDAC3HDAC2ALDH1A1KMT2AMAPT | |
| SCHEMBL8625140 | 0.80 | MAPT (0.59) | FFAR4KEAP1ALDH1A1LMNAMAPT | |
| SCHEMBL27181622 | 0.78 | KMT2A (0.75) | STAT3ALDH1A1KDM4ELMNAKMT2A | |
| SCHEMBL27180643 | 0.78 | KMT2A (0.75) | STAT3ALDH1A1KDM4ELMNAKMT2A | |
| SCHEMBL6935548 | 0.77 | ALDH1A1 (0.65) | HDAC3HDAC2ALDH1A1KDM4ECYP2C9 | |
| SCHEMBL27180903 | 0.77 | LMNA (0.62) | FFAR4STAT3HDAC3NCOR2HDAC2 | |
| SCHEMBL8626446 | 0.77 | STAT3 (0.63) | KEAP1STAT3HDAC3NCOR2HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5610320-A | ANTITUMOR AGENTS | EISAI CO., LTD. (JP) | 1997-03-11 | — | — | US | claimed |
| EP-0472053-B1 | Sulfonamide derivatives | EISAI CO LTD (JP) | 1998-06-17 | — | — | EP | disclosed |
| US-5610304-A | Pyrimidinyl or pyridinyl sulfonamide substituted compounds | EISAI CO., LTD. (JP) | 1997-03-11 | — | — | US | disclosed |
| US-5610320-A | ANTITUMOR AGENTS | EISAI CO., LTD. (JP) | 1997-03-11 | — | — | US | disclosed |
| US-5434172-A | Antitumor | EISAI CO., LTD. (JP) | 1995-07-18 | — | — | US | disclosed |
| US-5332751-A | Antitumor | EISAI CO., LTD. (JP) | 1994-07-26 | — | — | US | disclosed |
| US-5292758-A | Sulfonamide derivatives | EISAI CO., LTD. (JP) | 1994-03-08 | — | — | US | disclosed |
| US-5250549-A | Antitumor agents | EISAI CO., LTD. (JP) | 1993-10-05 | — | — | US | disclosed |
| EP-0472053-A2 | Sulfonamide derivatives | Eisai Co., Ltd. (JP) | 1992-02-26 | — | — | EP | disclosed |