Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.60 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.58 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.56 |
| ▸ | CCR9 | P51686 | 1/20 | 0.53 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.52 |
| ▸ | TUBB | P07437 | 1/20 | 0.52 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.52 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.52 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.52 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.52 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.52 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.52 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.52 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.52 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.52 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.52 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.52 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.52 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8622517 | 0.89 | FFAR4 (0.55) | SMN1; SMN2FFAR4KEAP1LMNAPKM | |
| SCHEMBL8628065 | 0.87 | FFAR4 (0.58) | FFAR4KEAP1TUBB4ATUBBTUBA3C | |
| SCHEMBL8626468 | 0.85 | SMN1; SMN2 (0.69) | SMN1; SMN2L3MBTL1KEAP1CCR9TUBB4A | |
| SCHEMBL8625140 | 0.84 | MAPT (0.59) | SMN1; SMN2L3MBTL1FFAR4KEAP1CCR9 | |
| SCHEMBL7249253 | 0.78 | F10 (0.69) | SMN1; SMN2PKMALDH1A1MEN1KMT2A | |
| SCHEMBL8625192 | 0.76 | F10 (0.67) | SMN1; SMN2L3MBTL1KEAP1TUBB4ATUBB | |
| SCHEMBL6359170 | 0.75 | MEN1 (0.68) | SMN1; SMN2L3MBTL1CCR9LMNAPKM | |
| SCHEMBL6935548 | 0.75 | ALDH1A1 (0.65) | SMN1; SMN2PKMALDH1A1MEN1KMT2A | |
| SCHEMBL8626192 | 0.74 | KEAP1 (0.56) | SMN1; SMN2L3MBTL1KEAP1CCR9TUBB4A | |
| SCHEMBL8623537 | 0.74 | KEAP1 (0.56) | SMN1; SMN2L3MBTL1KEAP1CCR9TUBB4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0472053-B1 | Sulfonamide derivatives | EISAI CO LTD (JP) | 1998-06-17 | — | — | EP | disclosed |
| US-5610304-A | Pyrimidinyl or pyridinyl sulfonamide substituted compounds | EISAI CO., LTD. (JP) | 1997-03-11 | — | — | US | disclosed |
| US-5610320-A | ANTITUMOR AGENTS | EISAI CO., LTD. (JP) | 1997-03-11 | — | — | US | disclosed |
| US-5434172-A | Antitumor | EISAI CO., LTD. (JP) | 1995-07-18 | — | — | US | disclosed |
| US-5332751-A | Antitumor | EISAI CO., LTD. (JP) | 1994-07-26 | — | — | US | disclosed |
| US-5292758-A | Sulfonamide derivatives | EISAI CO., LTD. (JP) | 1994-03-08 | — | — | US | disclosed |
| US-5250549-A | Antitumor agents | EISAI CO., LTD. (JP) | 1993-10-05 | — | — | US | disclosed |
| EP-0472053-A2 | Sulfonamide derivatives | Eisai Co., Ltd. (JP) | 1992-02-26 | — | — | EP | disclosed |