Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS2R46 | P59540 | 8/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.32 |
| ▸ | TAS2R31 | P59538 | 2/20 | 0.32 |
| ▸ | TAS2R10 | Q9NYW0 | 2/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9240553 | 1.00 | TAS2R46 (0.47) | TAS2R46MEN1KMT2ACYP1A2ALDH1A1 | |
| SCHEMBL8635163 | 1.00 | TAS2R46 (0.47) | TAS2R46MEN1KMT2ACYP1A2ALDH1A1 | |
| SCHEMBL754420 | 1.00 | TAS2R46 (0.47) | TAS2R46MEN1KMT2ACYP1A2ALDH1A1 | |
| SCHEMBL4097512 | 1.00 | TAS2R46 (0.47) | TAS2R46MEN1KMT2ACYP1A2ALDH1A1 | |
| SCHEMBL9244208 | 1.00 | TAS2R46 (0.47) | TAS2R46MEN1KMT2ACYP1A2ALDH1A1 | |
| SCHEMBL24026904 | 1.00 | TAS2R46 (0.47) | TAS2R46MEN1KMT2ACYP1A2ALDH1A1 | |
| SCHEMBL13478756 | 1.00 | TAS2R46 (0.47) | TAS2R46MEN1KMT2ACYP1A2ALDH1A1 | |
| SCHEMBL18629658 | 1.00 | TAS2R46 (0.47) | TAS2R46MEN1KMT2ACYP1A2ALDH1A1 | |
| SCHEMBL21316644 | 1.00 | TAS2R46 (0.47) | TAS2R46MEN1KMT2ACYP1A2ALDH1A1 | |
| SCHEMBL8632758 | 1.00 | TAS2R46 (0.47) | TAS2R46MEN1KMT2ACYP1A2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0621892-A1 | USE OF FURANONES AS SCENTING INGREDIENTS | FIRMENICH SA (CH) | 1994-11-02 | — | — | EP | claimed |
| WO-1994012143-A2 | USE OF FURANONES AS SCENTING INGREDIENTS | FIRMENICH SA (CH) | 1994-06-09 | — | — | WO | claimed |
| EP-3347348-B1 | PREPARATION OF 3-HYDROXY-3,6-DIMETHYLHEXAHYDROBENZOFURAN-2-ONE AND DERIVATIVES THEREOF | P2 SCIENCE INC (US) | 2021-11-17 | — | — | EP | disclosed |
| US-20210230132-A1 | PREPARATION OF 3-HYDROXY-3,6-DIMETHYLHEXAHYDROBENZOFURAN-2-ONE AND DERIVATIVES THEREOF | P2 SCIENCE, INC. (US) | 2021-07-29 | — | — | US | disclosed |
| US-11008299-B2 | Preparation of 3-hydroxy-3,6- dimethylhexahydrobenzofuran-2-one and derivatives thereof | P2 SCIENCE, INC. (US) | 2021-05-18 | — | — | US | disclosed |
| US-10995080-B2 | Stereoselective synthesis of perhydro-3,6-dialkyl-2-benzo[b]furanones and analogs | INTERNATIONAL FLAVOR & FRAGRANCES INC. (US) | 2021-05-04 | — | — | US | disclosed |
| US-20200377466-A1 | STEREOSELECTIVE SYNTHESIS OF PERHYDRO-3,6-DIALKYL-2-BENZO[B]FURANONES AND ANALOGS | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 2020-12-03 | — | — | US | disclosed |
| EP-3744717-A1 | STEREOSELECTIVE PREPARATION OF PERHYDRO-3,6-DIMETHYL-2-BENZO[B]FURANONES | International Flavors & Fragrances Inc. (US) | 2020-12-02 | — | — | EP | disclosed |
| US-20190322635-A1 | PREPARATION OF 3-HYDROXY-3,6-DIMETHYLHEXAHYDROBENZOFURAN-2-ONE AND DERIVATIVES THEREOF | P2 SCIENCE, INC. (US) | 2019-10-24 | — | — | US | disclosed |
| US-10399954-B2 | Preparation of 3-hydroxy-3,6-dimethylhexahydrobenzofuran-2-one and derivatives thereof | P2 SCIENCE, INC. (US) | 2019-09-03 | — | — | US | disclosed |
| US-20190002424-A1 | PREPARATION OF 3-HYDROXY-3,6-DIMETHYLHEXAHYDROBENZOFURAN-2-ONE AND DERIVATIVES THEREOF | P2 SCIENCE, INC. (US) | 2019-01-03 | — | — | US | disclosed |
| WO-2017044957-A1 | PREPARATION OF 3-HYDROXY-3,6-DIMETHYLHEXAHYDROBENZOFURAN-2-ONE AND DERIVATIVES THEREOF | P2 SCIENCE, INC. (US) | 2017-03-16 | — | — | WO | disclosed |
| EP-0621892-B1 | USE OF FURANONES AS SCENTING INGREDIENTS | FIRMENICH & CIE (CH) | 1998-07-08 | — | — | EP | disclosed |
| US-5464824-A | Odors and perfumed articles | FIRMENICH SA (CH) | 1995-11-07 | — | — | US | disclosed |
| EP-0621892-A1 | USE OF FURANONES AS SCENTING INGREDIENTS | FIRMENICH SA (CH) | 1994-11-02 | — | — | EP | disclosed |
| WO-1994012143-A2 | USE OF FURANONES AS SCENTING INGREDIENTS | FIRMENICH SA (CH) | 1994-06-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10995080-B2 | Stereoselective synthesis of perhydro-3,6-dialkyl-2-benzo[b]furanones and analogs | DLD, DHCR7, DHPS | TAS2R46 2430/4885MEN1 1593/4885KMT2A 2155/4885 |
| US-20200377466-A1 | STEREOSELECTIVE SYNTHESIS OF PERHYDRO-3,6-DIALKYL-2-BENZO[B]FURANONES AND ANALOGS | DLD, DHCR7, DHPS | TAS2R46 2430/4885MEN1 1593/4885KMT2A 2155/4885 |
| US-10399954-B2 | Preparation of 3-hydroxy-3,6-dimethylhexahydrobenzofuran-2-one and derivatives thereof | CYP8B1, DIMT1, DHCR7 | TAS2R46 4550/4885MEN1 91/4885KMT2A 312/4885 |
| US-20190002424-A1 | PREPARATION OF 3-HYDROXY-3,6-DIMETHYLHEXAHYDROBENZOFURAN-2-ONE AND DERIVATIVES THEREOF | CYP8B1, DIMT1, DHCR7 | TAS2R46 4550/4885MEN1 91/4885KMT2A 312/4885 |
| US-11008299-B2 | Preparation of 3-hydroxy-3,6- dimethylhexahydrobenzofuran-2-one and derivatives thereof | CYP8B1, DIMT1, DHCR7 | TAS2R46 4550/4885MEN1 91/4885KMT2A 312/4885 |
| US-20190322635-A1 | PREPARATION OF 3-HYDROXY-3,6-DIMETHYLHEXAHYDROBENZOFURAN-2-ONE AND DERIVATIVES THEREOF | CYP8B1, DIMT1, DHCR7 | TAS2R46 4550/4885MEN1 91/4885KMT2A 312/4885 |
| US-20210230132-A1 | PREPARATION OF 3-HYDROXY-3,6-DIMETHYLHEXAHYDROBENZOFURAN-2-ONE AND DERIVATIVES THEREOF | CYP8B1, DIMT1, DHCR7 | TAS2R46 4550/4885MEN1 91/4885KMT2A 312/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.