Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.48 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.45 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.45 |
| ▸ | CASR | P41180 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CCNC | P24863 | 1/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | TP53BP1 | Q12888 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8625971 | 0.88 | ALDH1A1 (0.52) | EPHX2CA1CA2PAX8GAA | |
| SCHEMBL8628814 | 0.87 | CASR (0.55) | EPHX2CA1CA2PAX8CASR | |
| SCHEMBL16152246 | 0.82 | SMN1; SMN2 (0.60) | CA1CA2GAASMN1; SMN2TP53BP1 | |
| SCHEMBL8623427 | 0.81 | EPHX2 (0.59) | EPHX2PAX8GAACASRLMNA | |
| SCHEMBL8897098 | 0.81 | NAMPT (0.56) | EPHX2CA1CA2LMNASMN1; SMN2 | |
| SCHEMBL31617997 | 0.81 | EPHX1 (0.58) | CA1CA2GAALMNACCNC | |
| SCHEMBL30684558 | 0.81 | PPARG (0.51) | LMNASMN1; SMN2HDAC3HDAC1HDAC2 | |
| SCHEMBL10169791 | 0.79 | CA1 (0.58) | CA1CA2PAX8GAACASR | |
| SCHEMBL29459203 | 0.79 | CA1 (0.58) | CA1CA2PAX8GAACASR | |
| SCHEMBL284884 | 0.78 | SMN1; SMN2 (0.59) | CA1CA2LMNASMN1; SMN2TP53BP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0689549-B1 | NEW UREA DERIVATES, THEIR PREPARATION AND THEIR USE | HOECHST AG (DE) | 1998-06-17 | — | — | EP | disclosed |
| US-5703050-A | INHIBIT PLATELET AGGREGATION, METASTASIS OF CARCINOMA CELLS, OSTEOCLAST BINDING TO BONE SURFACE | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-12-30 | — | — | US | disclosed |
| EP-0689549-A1 | NEW UREA DERIVATES, THEIR PREPARATION AND THEIR USE | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-01-03 | — | — | EP | disclosed |
| WO-1994022907-A1 | NEW UREA DERIVATES, THEIR PREPARATION AND THEIR USE | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-10-13 | — | — | WO | disclosed |