Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 7/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.34 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8630040 | 0.92 | POLB (0.36) | KDM4EHPGDPTGS2CYP3A4CYP2C9 | |
| SCHEMBL8629956 | 0.88 | PTGS2 (0.37) | KDM4EHPGDPTGS2CYP3A4CYP2C9 | |
| SCHEMBL8632316 | 0.87 | PTGS1 (0.40) | PTGDR2KDM4EHPGDPTGS2CYP3A4 | |
| SCHEMBL8631203 | 0.86 | PTGDR2 (0.46) | PTGDR2KDM4EHPGDPTGS2CYP3A4 | |
| SCHEMBL8633221 | 0.86 | PTGS2 (0.38) | KDM4EHPGDPTGS2CYP3A4CYP2C9 | |
| SCHEMBL8631579 | 0.85 | PTGS2 (0.42) | KDM4EHPGDPTGS2CYP3A4CYP2C9 | |
| SCHEMBL8635408 | 0.85 | PTGS2 (0.36) | KDM4EHPGDPTGS2CYP3A4CYP2C9 | |
| SCHEMBL7777609 | 0.83 | PTGS2 (0.49) | PTGS2PTGS1CA2CA9 | |
| SCHEMBL8630565 | 0.82 | PTGS2 (0.40) | PTGDR2KDM4EHPGDPTGS2CYP3A4 | |
| SCHEMBL8629079 | 0.81 | F10 (0.36) | KDM4EHPGDPTGS2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |