Hydrochloric Acid

Hydrochloric Acid

SCHEMBL8628712

CCC1=Cc2c(-c3ccccc3)cccc2C1[Zr+2]1(C2C(CC)=Cc3c(-c4ccccc4)cccc32)=[Si]2CC[Si]=1CC2.[Cl-].[Cl-]

nearest known ligand 0.31

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Known targets — ChEMBL curated mechanism

ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
HTR1A P08908 3/20 0.30
HTR7 P34969 3/20 0.30
ADRA2A P08913 1/20 0.30
ADRA2B P18089 1/20 0.30
ADRA2C P18825 1/20 0.30
CHRNB2 P17787 1/20 0.30
CHRNA4 P43681 1/20 0.30
HTR2B P41595 1/20 0.30
TMEM97 Q5BJF2 1/20 0.30
SIGMAR1 Q99720 1/20 0.30
KDM4E B2RXH2 1/20 0.30
ALDH1A1 P00352 1/20 0.30
KMT2A Q03164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL9069222 0.88
Hydrochloric Acid SCHEMBL8628846 0.87
Hydrochloric Acid SCHEMBL8636180 0.86
Hydrochloric Acid SCHEMBL4658161 0.84 HTR1A (0.32) HTR1AHTR7CHRNB2CHRNA4HTR2B
Hydrochloric Acid SCHEMBL8628713 0.84 ADRA2A (0.33) HTR1AHTR7ADRA2AADRA2BADRA2C
Hydrochloric Acid SCHEMBL6891980 0.82 HTR1A (0.30) HTR1AHTR7CHRNB2CHRNA4HTR2B
Fluoride Ion SCHEMBL7644991 0.82 HTR1A (0.32) HTR1AHTR7CHRNB2CHRNA4HTR2B
Hydrochloric Acid SCHEMBL6889790 0.81 HTR1A (0.32) HTR1AHTR7HTR2BTMEM97SIGMAR1
Hydrochloric Acid SCHEMBL9068889 0.81
Hydrochloric Acid SCHEMBL9069168 0.80 ADRA2A (0.31) ADRA2AADRA2BADRA2C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5776851-A COORDINATION POLYMERIZATION CATALYST TARGOR GMBH (DE) 1998-07-07 US claimed
US-5585508-A POLYMERIZATION CATALYST FOR POLYOLEFINS HOECHST AG (DE) 1996-12-17 US claimed
US-5776851-A COORDINATION POLYMERIZATION CATALYST TARGOR GMBH (DE) 1998-07-07 US disclosed
US-5693730-A METALLOCENES HAVING MORE THAN ONE CENTRAL ATOM AND A SPECIAL BRIDGE STRUCTURE FOR PREPARING ISOTACTIC, HIGH-MOLECULAR-WEIGHT POLYMERS HAVING GOOD GRAIN MORPHOLOGY; PROPYLENE HOMO- AND COPOLYMERS HOECHST AKTIENGESELLSCHAFT (DE) 1997-12-02 US disclosed
US-5585508-A POLYMERIZATION CATALYST FOR POLYOLEFINS HOECHST AG (DE) 1996-12-17 US disclosed