Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 3/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 5/20 | 0.32 |
| ▸ | HTR1A | P08908 | 4/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 3/20 | 0.31 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.30 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9069168 | 0.95 | ADRA2A (0.31) | ADRA2AADRA2BADRA2CPDK2PDK4 | |
| Hydrochloric Acid SCHEMBL9068908 | 0.91 | FFAR2 (0.30) | — | |
| Hydrochloric Acid SCHEMBL9069774 | 0.91 | PDK2 (0.34) | PDK2PDK4 | |
| Hydrochloric Acid SCHEMBL9069222 | 0.88 | — | — | |
| Hydrochloric Acid SCHEMBL9069315 | 0.87 | — | — | |
| Hydrochloric Acid SCHEMBL9068695 | 0.85 | ROCK2 (0.31) | — | |
| Hydrochloric Acid SCHEMBL8635789 | 0.85 | PDK2 (0.30) | PDK2PDK4 | |
| Hydrochloric Acid SCHEMBL8628712 | 0.84 | HTR1A (0.30) | ADRA2AADRA2BADRA2CHTR7HTR1A | |
| Hydrochloric Acid SCHEMBL8632675 | 0.84 | BRD4 (0.30) | PDK2PDK4BRD4 | |
| Hydrochloric Acid SCHEMBL390312 | 0.82 | USP30 (0.33) | PDK2PDK4HTR7HTR1AUSP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5776851-A | COORDINATION POLYMERIZATION CATALYST | TARGOR GMBH (DE) | 1998-07-07 | — | — | US | claimed |
| US-5776851-A | COORDINATION POLYMERIZATION CATALYST | TARGOR GMBH (DE) | 1998-07-07 | — | — | US | disclosed |
| US-5693730-A | METALLOCENES HAVING MORE THAN ONE CENTRAL ATOM AND A SPECIAL BRIDGE STRUCTURE FOR PREPARING ISOTACTIC, HIGH-MOLECULAR-WEIGHT POLYMERS HAVING GOOD GRAIN MORPHOLOGY; PROPYLENE HOMO- AND COPOLYMERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-12-02 | — | — | US | disclosed |
| US-5585508-A | POLYMERIZATION CATALYST FOR POLYOLEFINS | HOECHST AG (DE) | 1996-12-17 | — | — | US | disclosed |