Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 1/20 | 0.44 |
| ▸ | EDNRA | P25101 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 2/20 | 0.43 |
| ▸ | CDC7 | O00311 | 2/20 | 0.42 |
| ▸ | MALT1 | Q9UDY8 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | PLEC | Q15149 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8631666 | 0.91 | EDNRB (0.42) | EDNRBEDNRAKDM1AMALT1MEN1 | |
| SCHEMBL8634658 | 0.90 | PTGS2 (0.46) | EDNRACDC7MALT1MEN1LMNA | |
| SCHEMBL8629794 | 0.89 | SMN1; SMN2 (0.46) | EDNRBEDNRAKDM1AMEN1KMT2A | |
| SCHEMBL8630518 | 0.86 | AR (0.43) | EDNRBEDNRAKDM1ACDC7MEN1 | |
| SCHEMBL8628070 | 0.86 | MEN1 (0.43) | EDNRBEDNRAKDM1AMALT1MEN1 | |
| SCHEMBL8633218 | 0.86 | EDNRB (0.42) | EDNRBEDNRAKDM1AMALT1MEN1 | |
| SCHEMBL8631200 | 0.84 | PTGDR2 (0.48) | KDM1ACDC7MALT1MEN1LMNA | |
| SCHEMBL8631830 | 0.83 | CDC7 (0.44) | EDNRBEDNRAKDM1ACDC7MALT1 | |
| SCHEMBL8631602 | 0.82 | CDC25A (0.43) | EDNRBEDNRAKDM1ACDC7MEN1 | |
| SCHEMBL8629982 | 0.82 | EDNRB (0.43) | EDNRBEDNRAKDM1ACDC7MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |