Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | FPR1 | P21462 | 1/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.39 |
| ▸ | EDNRA | P25101 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8628755 | 0.90 | EDNRB (0.44) | ALDH1A1PTGDR2KDM4EMAPTMEN1 | |
| SCHEMBL8633612 | 0.90 | GAA (0.45) | PTGS2ALDH1A1FPR1KDM4EMAPT | |
| SCHEMBL8633689 | 0.89 | SMN1; SMN2 (0.50) | ALDH1A1FPR1KDM4EMAPTMEN1 | |
| SCHEMBL8635571 | 0.87 | PTGDR2 (0.48) | PTGS2ALDH1A1FPR1PTGDR2KDM4E | |
| SCHEMBL8631394 | 0.87 | AR (0.43) | PTGS2ALDH1A1FPR1PTGDR2KDM4E | |
| SCHEMBL8631693 | 0.85 | MAPT (0.40) | ALDH1A1FPR1KDM4EMAPTMEN1 | |
| SCHEMBL8634444 | 0.85 | SMN1; SMN2 (0.42) | ALDH1A1FPR1KDM4EMAPTMEN1 | |
| SCHEMBL8629928 | 0.82 | PTGS2 (0.43) | PTGS2ALDH1A1FPR1PTGDR2KDM4E | |
| SCHEMBL8635042 | 0.82 | PDE9A (0.43) | PTGS2ALDH1A1FPR1PTGDR2KDM4E | |
| SCHEMBL8628874 | 0.82 | PTGS2 (0.43) | PTGS2ALDH1A1FPR1PTGDR2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |