Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FTO | Q9C0B1 | 7/20 | 0.50 |
| ▸ | KDM6B | O15054 | 2/20 | 0.50 |
| ▸ | EGLN1 | Q9GZT9 | 12/20 | 0.48 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.44 |
| ▸ | KDM5B | Q9UGL1 | 3/20 | 0.42 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.42 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.42 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 4/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.40 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8629451 | 0.86 | EGLN1 (0.55) | FTOKDM6BEGLN1HIF1ANKDM5B | |
| SCHEMBL6564105 | 0.86 | EGLN1 (0.48) | FTOKDM6BEGLN1HIF1ANKDM5B | |
| SCHEMBL8627667 | 0.82 | EGLN1 (0.51) | FTOKDM6BEGLN1HIF1ANKDM5B | |
| SCHEMBL8629264 | 0.80 | EGLN1 (0.51) | FTOEGLN1HIF1ANKDM5BKDM2A | |
| SCHEMBL8628250 | 0.80 | EGLN1 (0.46) | FTOKDM6BEGLN1HIF1ANKDM5B | |
| SCHEMBL6567419 | 0.80 | EGLN1 (0.51) | FTOEGLN1HIF1ANKDM5BKDM2A | |
| SCHEMBL8626818 | 0.80 | EGLN1 (0.44) | FTOEGLN1HIF1ANKDM5BKDM2A | |
| SCHEMBL8629275 | 0.79 | EGLN1 (0.44) | FTOEGLN1HIF1ANKDM5BKDM2A | |
| SCHEMBL8628694 | 0.79 | EGLN1 (0.45) | FTOEGLN1HIF1ANKDM5BKDM2A | |
| SCHEMBL8628459 | 0.79 | EGLN1 (0.46) | EGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5726305-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-03-10 | — | — | US | disclosed |
| US-5719164-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-02-17 | — | — | US | disclosed |
| CN-1154365-A | Substituted quinoline-2-carboxamides, process for their preparation and their use as pharmaceuticals, and intermediates thereof | HOECHST AG (DE) | 1997-07-16 | — | — | CN | disclosed |
| EP-0765871-A1 | Substituted Quinoline-2-carboxamides, their preparation and their use as prolyle-4-hydroxylase Inhibitors | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-04-02 | — | — | EP | disclosed |