Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 4/20 | 0.62 |
| ▸ | NCOR2 | Q9Y618 | 4/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.62 |
| ▸ | NPC1 | O15118 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.55 |
| ▸ | STAT3 | P40763 | 1/20 | 0.54 |
| ▸ | CCR8 | P51685 | 1/20 | 0.53 |
| ▸ | SQSTM1 | Q13501 | 1/20 | 0.53 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.53 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8627623 | 0.87 | F10 (0.64) | HDAC3NCOR2KDM4EALDH1A1HDAC2 | |
| SCHEMBL8625192 | 0.87 | F10 (0.67) | HDAC3NCOR2KDM4EALDH1A1HDAC2 | |
| SCHEMBL28432 | 0.84 | CCR9 (0.62) | KDM4EALDH1A1SMN1; SMN2GAAKMT2A | |
| SCHEMBL8628289 | 0.81 | TUBB4A (0.61) | ALDH1A1SMN1; SMN2GAAKMT2AMAPT | |
| SCHEMBL27180903 | 0.81 | LMNA (0.62) | HDAC3NCOR2KDM4EALDH1A1HDAC2 | |
| SCHEMBL7251068 | 0.80 | NPC1 (0.81) | KDM4EALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8625225 | 0.80 | GPR27 (0.60) | HDAC3NCOR2KDM4EALDH1A1HDAC2 | |
| SCHEMBL8625679 | 0.79 | TUBB4A (0.68) | HDAC3NCOR2ALDH1A1HDAC2SMN1; SMN2 | |
| SCHEMBL8625306 | 0.79 | MEN1 (0.61) | HDAC3NCOR2ALDH1A1HDAC2SMN1; SMN2 | |
| SCHEMBL7411341 | 0.78 | MEN1 (0.65) | HDAC3NCOR2ALDH1A1HDAC2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5610320-A | ANTITUMOR AGENTS | EISAI CO., LTD. (JP) | 1997-03-11 | — | — | US | claimed |
| EP-0472053-B1 | Sulfonamide derivatives | EISAI CO LTD (JP) | 1998-06-17 | — | — | EP | disclosed |
| US-5610304-A | Pyrimidinyl or pyridinyl sulfonamide substituted compounds | EISAI CO., LTD. (JP) | 1997-03-11 | — | — | US | disclosed |
| US-5610320-A | ANTITUMOR AGENTS | EISAI CO., LTD. (JP) | 1997-03-11 | — | — | US | disclosed |
| US-5434172-A | Antitumor | EISAI CO., LTD. (JP) | 1995-07-18 | — | — | US | disclosed |
| US-5332751-A | Antitumor | EISAI CO., LTD. (JP) | 1994-07-26 | — | — | US | disclosed |
| US-5292758-A | Sulfonamide derivatives | EISAI CO., LTD. (JP) | 1994-03-08 | — | — | US | disclosed |
| US-5250549-A | Antitumor agents | EISAI CO., LTD. (JP) | 1993-10-05 | — | — | US | disclosed |
| EP-0472053-A2 | Sulfonamide derivatives | Eisai Co., Ltd. (JP) | 1992-02-26 | — | — | EP | disclosed |