SCHEMBL8629217

SCHEMBL8629217

Cn1[c]nnc1-c1cccnc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.47
CYP2A6 P11509 5/20 0.47
CYP1A2 P05177 2/20 0.47
CYP3A4 P08684 2/20 0.47
HTT P42858 2/20 0.46
HSD17B10 Q99714 2/20 0.46
LMNA P02545 2/20 0.46
KDM4E B2RXH2 1/20 0.46
TP53 P04637 1/20 0.46
MAPT P10636 1/20 0.46
HPGD P15428 1/20 0.46
ALOX15 P16050 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
CYP2A13 Q16696 1/20 0.45
GAA P10253 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
USP2 O75604 1/20 0.43
NCOA1 Q15788 1/20 0.43
NCOA3 Q9Y6Q9 1/20 0.43
CYP2C9 P11712 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8629015 0.80 LMNA (0.43) ALDH1A1CYP2A6CYP1A2CYP3A4HTT
SCHEMBL4391055 0.80 KMT2A (0.43) ALDH1A1LMNAL3MBTL1TSHRRAB9A
SCHEMBL8631055 0.79 CYP2C19 (0.47) ALDH1A1CYP2A6CYP1A2CYP3A4HTT
SCHEMBL12704750 0.71 ALDH1A1 (0.50) ALDH1A1CYP2A6CYP1A2CYP3A4HTT
SCHEMBL21811859 0.70 CYP2A6 (0.50) ALDH1A1CYP2A6CYP1A2CYP3A4HTT
SCHEMBL28429543 0.70 KMT2A (0.61) ALDH1A1CYP2A6CYP1A2CYP3A4HTT
SCHEMBL1544974 0.69 ALDH1A1 (0.50) ALDH1A1CYP2A6CYP1A2CYP3A4HTT
SCHEMBL12320458 0.68 CYP2A6 (0.56) ALDH1A1CYP2A6CYP1A2CYP3A4HTT
SCHEMBL8631747 0.68 ALDH1A1 (0.37) ALDH1A1CYP1A2CYP3A4HTTHSD17B10
SCHEMBL31700259 0.68 CYP2A6 (0.56) ALDH1A1CYP2A6CYP1A2CYP3A4HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE35754-E FOR TREATING BACTERIAL INFECTIONS HOECHST AKTIENGESELLSCHAFT (DE) 1998-03-24 US disclosed
US-5710146-A ANTIBIOTICS FOR BACTERICIDES HOECHST AKTIENGESELLSCHAFT (DE) 1998-01-20 US disclosed
US-5089490-A Cephem derivatives HOECHST AKTIENGESELLSCHAFT (DE) 1992-02-18 US disclosed
US-4758556-A Cephem derivatives HOECHST AKTIENGESELLSCHAFT (DE) 1988-07-19 US disclosed
US-4399131-A Cephem derivatives HOECHST AG (DE) 1983-08-16 US disclosed
US-4278793-A ANTIBIOTICS, BACTERICIDES HOECHST AKTIENGESELLSCHAFT (DE) 1981-07-14 US disclosed