Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.54 |
| ▸ | HTR2C | P28335 | 1/20 | 0.54 |
| ▸ | SORD | Q00796 | 2/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
| ▸ | HTR1B | P28222 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | GRM4 | Q14833 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8635560 | 0.83 | HRH4 (0.49) | HRH4HTR2CSORDHTR1AHTR1D | |
| SCHEMBL8797245 | 0.81 | POLB (0.62) | HTR1ADRD4POLBLMNATSHR | |
| SCHEMBL30041280 | 0.80 | HRH4 (0.57) | HRH4HTR2CSORDHTR1AHTR1D | |
| SCHEMBL23964309 | 0.80 | HRH4 (0.57) | HRH4HTR2CSORDHTR1AHTR1D | |
| SCHEMBL6232120 | 0.79 | HRH4 (0.62) | HRH4HTR2CSORDHTR1ADRD4 | |
| SCHEMBL8797465 | 0.79 | KMT2A (0.61) | HTR1ADRD4LMNAALDH1A1MAPT | |
| SCHEMBL8627719 | 0.78 | DRD4 (0.58) | HTR1ADRD4LMNAHTTALDH1A1 | |
| SCHEMBL8797340 | 0.77 | HTR3A (0.51) | HTR1ADRD4POLBLMNATSHR | |
| SCHEMBL3683535 | 0.76 | HRH4 (0.70) | HRH4HTR2CSORDLMNATSHR | |
| SCHEMBL8134359 | 0.76 | MEN1 (0.58) | HRH4HTR2CSORDHTR1AHTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5780475-A | Antipsychotic indazole derivatives | MERCK, SHARP & DOHME LIMITED (GB) | 1998-07-14 | — | — | US | disclosed |