Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | SORD | Q00796 | 2/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | DRD4 | P21917 | 2/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | HTR1D | P28221 | 1/20 | 0.40 |
| ▸ | HTR1B | P28222 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8629239 | 0.83 | HRH4 (0.54) | HRH4HTR2CSORDDRD4ALDH1A1 | |
| SCHEMBL8651329 | 0.80 | HTR3A (0.46) | DRD2DRD3DRD4KCNH2MAPT | |
| SCHEMBL6232120 | 0.77 | HRH4 (0.62) | HRH4HTR2CSORDDRD4ALDH1A1 | |
| SCHEMBL8628752 | 0.77 | KDM4E (0.54) | HTR2CDRD2DRD3DRD4ADRA1A | |
| SCHEMBL8134359 | 0.77 | MEN1 (0.58) | HRH4HTR2CSORDDRD4ALDH1A1 | |
| SCHEMBL8630558 | 0.76 | ALDH1A1 (0.43) | HTR2CDRD2DRD3DRD4ALDH1A1 | |
| SCHEMBL8130723 | 0.75 | SIGMAR1 (0.58) | HRH4HTR2CSORDDRD4ALDH1A1 | |
| SCHEMBL8629820 | 0.75 | KDM4E (0.45) | HTR2CDRD2DRD3DRD4ADRA1A | |
| SCHEMBL3684916 | 0.73 | KDM4E (0.59) | HRH4HTR2CSORDALDH1A1MAPT | |
| SCHEMBL8486348 | 0.73 | HRH4 (0.60) | HRH4HTR2CSORDALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5780475-A | Antipsychotic indazole derivatives | MERCK, SHARP & DOHME LIMITED (GB) | 1998-07-14 | — | — | US | disclosed |