Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPD | P32754 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | TTR | P02766 | 1/20 | 0.50 |
| ▸ | PPOX | P50336 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PTGES | O14684 | 2/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8633063 | 0.85 | SIRT6 (0.47) | HPDMEN1KMT2ATDP1TTR | |
| SCHEMBL8630071 | 0.84 | PIN1 (0.46) | TDP1SMN1; SMN2POLBMAPTMAPK1 | |
| SCHEMBL6567283 | 0.84 | MEN1 (0.68) | MEN1KMT2ATDP1TTRPPOX | |
| SCHEMBL25245711 | 0.83 | TDP1 (0.55) | MEN1KMT2ATDP1TTRPPOX | |
| SCHEMBL10788540 | 0.83 | TDP1 (0.50) | MEN1KMT2ATDP1TTRPPOX | |
| SCHEMBL8628865 | 0.80 | HPD (0.47) | HPDMEN1KMT2ATDP1TTR | |
| SCHEMBL6564069 | 0.80 | MEN1 (0.48) | MEN1KMT2ATDP1TTRPPOX | |
| SCHEMBL6567167 | 0.78 | MAPT (0.49) | MEN1KMT2ATDP1TTRPPOX | |
| SCHEMBL6564098 | 0.77 | AKR1C3 (0.47) | HPDTDP1LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL11126332 | 0.77 | TDP1 (0.58) | HPDMEN1KMT2ATDP1TTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5726305-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-03-10 | — | — | US | disclosed |
| US-5719164-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-02-17 | — | — | US | disclosed |