Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.47 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TLR4 | O00206 | 1/20 | 0.43 |
| ▸ | TLR2 | O60603 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | XDH | P47989 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.41 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | TTR | P02766 | 2/20 | 0.41 |
| ▸ | PPOX | P50336 | 1/20 | 0.41 |
| ▸ | HPD | P32754 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8630071 | 0.89 | PIN1 (0.46) | KDM4ETDP1AKR1C3AKR1C2AKR1B10 | |
| SCHEMBL8629336 | 0.85 | HPD (0.52) | TDP1AKR1C3AKR1C2AKR1B1AKR1C4 | |
| SCHEMBL6564098 | 0.84 | AKR1C3 (0.47) | KDM4ETDP1AKR1C3AKR1C2AKR1B10 | |
| SCHEMBL3889423 | 0.82 | MEN1 (0.55) | SIRT6HPSEKDM4ETDP1AKR1C3 | |
| SCHEMBL2724028 | 0.80 | TDP1 (0.62) | SIRT6HPSEKDM4ETDP1XDH | |
| SCHEMBL27354736 | 0.80 | PARP10 (0.50) | SIRT6HPSEKDM4ETDP1XDH | |
| SCHEMBL4270245 | 0.80 | SIRT6 (0.53) | SIRT6KDM4ETDP1XDHAKR1C3 | |
| SCHEMBL8628865 | 0.80 | HPD (0.47) | SIRT6TDP1HTR6MEN1KMT2A | |
| SCHEMBL8630905 | 0.79 | MAPT (0.50) | KDM4ETLR4TLR2TDP1AKR1C3 | |
| SCHEMBL2971944 | 0.77 | ALDH1A1 (0.54) | KDM4ETDP1HPDCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5726305-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-03-10 | — | — | US | disclosed |
| US-5719164-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-02-17 | — | — | US | disclosed |