Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 4/20 | 0.44 |
| ▸ | FEN1 | P39748 | 4/20 | 0.44 |
| ▸ | F10 | P00742 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PTGES2 | Q9H7Z7 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8631181 | 0.86 | PTGS2 (0.50) | ALOX5APFEN1CA9TRPV1 | |
| SCHEMBL8632289 | 0.85 | AKR1B1 (0.40) | F10CA12CA2CA9TRPV1 | |
| SCHEMBL8631662 | 0.85 | F10 (0.42) | F10PTGES2CA12CA2CA9 | |
| SCHEMBL8631346 | 0.85 | NPC1 (0.40) | ALOX5APFEN1MAPTNFKB1NFKB2 | |
| SCHEMBL8632812 | 0.84 | ALOX5AP (0.47) | ALOX5APFEN1F10TRPV1 | |
| SCHEMBL7779754 | 0.84 | MAP2K4 (0.51) | CA12CA2CA9TDO2MAP2K4 | |
| SCHEMBL2566974 | 0.82 | ALOX5AP (0.56) | ALOX5APFEN1F10PTGES2CA12 | |
| SCHEMBL8631499 | 0.81 | FABP1 (0.41) | ALOX5APFEN1PTGES2CA12CA2 | |
| SCHEMBL8629397 | 0.80 | ALOX5AP (0.40) | ALOX5APFEN1PTGES2CA12CA2 | |
| SCHEMBL8629321 | 0.80 | PTGS2 (0.59) | ALOX5APFEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |