Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | BACE1 | P56817 | 2/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | MMP3 | P08254 | 4/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | MMP14 | P50281 | 1/20 | 0.43 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12215061 | 0.87 | MAPT (0.48) | TAS2R14MAPTHTTNPSR1KDM4E | |
| SCHEMBL28211577 | 0.86 | TAS2R14 (0.65) | TAS2R14MAPTNPSR1GLAMMP3 | |
| SCHEMBL7641340 | 0.85 | MMP1 (0.57) | TAS2R14BACE1MMP3MMP1MMP8 | |
| SCHEMBL5190476 | 0.78 | TAS2R14 (0.63) | TAS2R14GLAMMP3MMP1MMP2 | |
| SCHEMBL9187490 | 0.77 | GLA (0.53) | TAS2R14MAPTHTTLMNAGLA | |
| SCHEMBL6954421 | 0.76 | TAS2R14 (0.53) | TAS2R14GLAMMP3KMT2ARORC | |
| SCHEMBL16727690 | 0.75 | SPPL2A (0.73) | TAS2R14LMNAPSEN1PSEN2APH1B | |
| SCHEMBL7347286 | 0.74 | MMP3 (0.76) | TAS2R14MMP3MMP1MMP2MMP9 | |
| SCHEMBL8896462 | 0.74 | GLA (0.50) | TAS2R14MAPTHTTNPSR1KDM4E | |
| SCHEMBL23129729 | 0.74 | TAS2R14 (0.54) | TAS2R14LMNAMMP3MMP1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5811462-A | (BICYCLO(2.2.1)HEPT-5'-EN-2'-YL-CARBONYL)AMINO-3-HYDROXY DERIVATIVES | MERCK & CO., INC. (US) | 1998-09-22 | — | — | US | disclosed |