Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | EDNRA | P25101 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | USP1 | O94782 | 1/20 | 0.37 |
| ▸ | USP8 | P40818 | 1/20 | 0.37 |
| ▸ | OTUB1 | Q96FW1 | 1/20 | 0.37 |
| ▸ | USP36 | Q9P275 | 1/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8632289 | 0.86 | AKR1B1 (0.40) | CA2CA12CA1CA9PTGS2 | |
| SCHEMBL8630958 | 0.85 | LRRK2 (0.48) | CA2CA1 | |
| SCHEMBL5488230 | 0.83 | CA2 (0.56) | CA2CA12CA1CA9PTGS2 | |
| SCHEMBL7772942 | 0.83 | CA2 (0.62) | CA2CA12CA1CA9PTGS2 | |
| SCHEMBL8632961 | 0.80 | F10 (0.40) | CA2CA12CA1CA9ALOX5AP | |
| SCHEMBL8634768 | 0.79 | F10 (0.42) | CA2CA12CA1CA9ALOX5AP | |
| SCHEMBL8627977 | 0.79 | PTGS2 (0.50) | CA2CA12CA1CA9PTGS2 | |
| SCHEMBL8632840 | 0.79 | LRRK2 (0.42) | CA2CA12CA1CA9PTGS2 | |
| SCHEMBL8631181 | 0.79 | PTGS2 (0.50) | CA9PTGS2ALOX5APFEN1 | |
| SCHEMBL8631346 | 0.79 | NPC1 (0.40) | CA2CA1DYRK1ANAMPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |