SCHEMBL8633160

SCHEMBL8633160

C=CCn1nc(NS(=O)(=O)c2ccccc2)c(-c2ccc(Cl)cc2)c1C#N

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 4/20 0.43
KMT2A Q03164 4/20 0.43
KDM1A O60341 2/20 0.40
EDNRB P24530 1/20 0.37
EDNRA P25101 1/20 0.37
NAT1 P18440 1/20 0.37
MAPT P10636 3/20 0.37
ALDH1A1 P00352 4/20 0.37
POLB P06746 3/20 0.37
KDM4E B2RXH2 4/20 0.36
LMNA P02545 3/20 0.36
HTT P42858 2/20 0.36
MAPK1 P28482 1/20 0.36
BLM P54132 1/20 0.36
ATM Q13315 1/20 0.36
PLEC Q15149 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
GAA P10253 3/20 0.36
HPGD P15428 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8627617 0.90 SMN1; SMN2 (0.42) MEN1KMT2AMAPTALDH1A1POLB
SCHEMBL8629951 0.87 MAPT (0.43) MEN1KMT2AKDM1AEDNRBEDNRA
SCHEMBL8631602 0.87 CDC25A (0.43) MEN1KMT2AKDM1AEDNRBEDNRA
SCHEMBL8629350 0.87 SMN1; SMN2 (0.46) MEN1KMT2AKDM1AEDNRBEDNRA
SCHEMBL8630029 0.85 MEN1 (0.45) MEN1KMT2AKDM1AEDNRBEDNRA
SCHEMBL8628554 0.84 PRMT1 (0.41) MEN1KMT2AKDM1AEDNRBEDNRA
SCHEMBL8632801 0.83 MEN1 (0.43) MEN1KMT2AKDM1AEDNRBEDNRA
SCHEMBL8628070 0.83 MEN1 (0.43) MEN1KMT2AKDM1AEDNRBEDNRA
SCHEMBL8629761 0.82 PTGS2 (0.48) MEN1KMT2AKDM1AEDNRBEDNRA
SCHEMBL8632242 0.81 ACLY (0.41) KDM1AEDNRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6001533-A LIGHT-SHIELDING LAYER CONTAINS AN ALKALI-SOLUBLE BINDER, A PHOTOPOLYMERIZABLE MONOMER, A PHOTOINITIATOR, A SOLVENT, AND A PIGMENT COMPRISES MIXED OXIDE OF COPPER-MANGANESE IN WHICH A PART OF MANGANESE IS REPLACED WITH IRON, COBALT OR NICKEL DAI NIPPON PRINTING CO., LTD. (JP) 1999-12-14 US disclosed