Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | OXTR | P30559 | 1/20 | 0.37 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.37 |
| ▸ | CYTH2 | Q99418 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | SDHB | P21912 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8629978 | 0.85 | MAPT (0.43) | MAPTMEN1KMT2ASMN1; SMN2FFAR4 | |
| SCHEMBL8630200 | 0.85 | MAPT (0.50) | MAPTMEN1KMT2ASMN1; SMN2FFAR4 | |
| SCHEMBL8628005 | 0.84 | MAPT (0.47) | MAPTMEN1KMT2AFFAR4PTGS2 | |
| SCHEMBL8632871 | 0.84 | MAPT (0.42) | MAPTMEN1KMT2ASMN1; SMN2PTGS2 | |
| SCHEMBL8629100 | 0.83 | MAPT (0.40) | MAPTMEN1KMT2ASMN1; SMN2PTGS2 | |
| SCHEMBL8631755 | 0.83 | MAPT (0.42) | MAPTMEN1KMT2ASMN1; SMN2PTGS2 | |
| SCHEMBL8629408 | 0.82 | MAPT (0.41) | MAPTMEN1KMT2ASMN1; SMN2FFAR4 | |
| SCHEMBL8633150 | 0.82 | MAPT (0.41) | MAPTMEN1KMT2ASMN1; SMN2FFAR4 | |
| SCHEMBL8631097 | 0.82 | PTGS2 (0.43) | MAPTMEN1KMT2ASMN1; SMN2FFAR4 | |
| SCHEMBL8631259 | 0.81 | HSD11B1 (0.39) | MEN1KMT2ASMN1; SMN2PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |