Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 18/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8696283 | 0.83 | ALOX5 (0.41) | ALOX5 | |
| SCHEMBL8696312 | 0.79 | ALOX5 (0.41) | ALOX5 | |
| SCHEMBL8630364 | 0.76 | ALOX5 (0.42) | ALOX5 | |
| SCHEMBL9100221 | 0.75 | ALOX5 (0.41) | ALOX5 | |
| SCHEMBL8698139 | 0.74 | ALOX5 (0.51) | ALOX5 | |
| SCHEMBL9100023 | 0.73 | ALOX5 (0.45) | ALOX5 | |
| SCHEMBL8694243 | 0.73 | ALOX5 (0.36) | ALOX5 | |
| SCHEMBL9255827 | 0.73 | ALOX5 (0.40) | ALOX5 | |
| SCHEMBL8698235 | 0.73 | ALOX5 (0.42) | ALOX5 | |
| SCHEMBL8698520 | 0.72 | ALOX5 (0.46) | ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5753682-A | Imidazole lipoxygenase inhibitors | PFIZER INC. (US) | 1998-05-19 | — | — | US | disclosed |
| EP-0828736-A1 | SUBSTITUTED SULFONYLPHENYLHETEROCYCLES AS CYCLOOXYGENASE-2 AND 5-LIPOXYGENASE INHIBITORS | G.D. SEARLE & CO. (US) | 1998-03-18 | — | — | EP | disclosed |
| EP-0703913-B1 | IMIDAZOLES AS LIPOXYGENASE INHIBITORS | PFIZER (US) | 1997-06-11 | — | — | EP | disclosed |
| WO-1996038442-A1 | SUBSTITUTED SULFONYLPHENYLHETEROCYCLES AS CYCLOOXYGENASE-2 AND 5-LIPOXYGENASE INHIBITORS | G.D. SEARLE & CO. (US) | 1996-12-05 | — | — | WO | disclosed |
| EP-0703913-A1 | IMIDAZOLE LIPOXYGENASE INHIBITORS | PFIZER (US) | 1996-04-03 | — | — | EP | disclosed |
| WO-1994029299-A1 | IMIDAZOLE LIPOXYGENASE INHIBITORS | PFIZER INC. (US) | 1994-12-22 | — | — | WO | disclosed |