Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 14/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | PDE1A | P54750 | 1/20 | 0.32 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.32 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8698520 | 0.85 | ALOX5 (0.46) | ALOX5 | |
| SCHEMBL9255827 | 0.79 | ALOX5 (0.40) | ALOX5 | |
| SCHEMBL8694243 | 0.79 | ALOX5 (0.36) | ALOX5PDE1APDE1BPDE1C | |
| SCHEMBL8696312 | 0.79 | ALOX5 (0.41) | ALOX5 | |
| SCHEMBL8696283 | 0.74 | ALOX5 (0.41) | ALOX5 | |
| SCHEMBL8630367 | 0.73 | ALOX5 (0.43) | ALOX5 | |
| SCHEMBL2048287 | 0.73 | TSHR (0.46) | ALOX5CYP3A4 | |
| SCHEMBL8630364 | 0.70 | ALOX5 (0.42) | ALOX5 | |
| SCHEMBL3565566 | 0.69 | OPRM1 (0.38) | ALOX5CYP2C19 | |
| SCHEMBL1599480 | 0.69 | ALOX5 (0.54) | ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5753682-A | Imidazole lipoxygenase inhibitors | PFIZER INC. (US) | 1998-05-19 | — | — | US | disclosed |
| EP-0703913-B1 | IMIDAZOLES AS LIPOXYGENASE INHIBITORS | PFIZER (US) | 1997-06-11 | — | — | EP | disclosed |