Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 12/20 | 0.55 |
| ▸ | HRH1 | P35367 | 6/20 | 0.55 |
| ▸ | HRH2 | P25021 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.48 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 2/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8635826 | 0.94 | HRH3 (0.54) | HRH3HRH1HRH2MAPTNPC1 | |
| Hydrochloric Acid SCHEMBL8681084 | 0.93 | HRH3 (0.53) | HRH3HRH1HRH2MAPTNPC1 | |
| SCHEMBL8701064 | 0.79 | SLC2A1 (0.46) | HRH3MAPTNPC1SMN1; SMN2ITGB3 | |
| SCHEMBL8634522 | 0.78 | HRH3 (0.47) | HRH3HRH1HRH2MAPTNPC1 | |
| Hydrochloric Acid SCHEMBL8837964 | 0.78 | ITGB3 (0.45) | HRH3ITGB3ITGA2BCYP2C9TSHR | |
| SCHEMBL8634143 | 0.76 | SLC2A1 (0.47) | MAPTNPC1SMN1; SMN2ITGB3ITGA2B | |
| SCHEMBL8635011 | 0.76 | ITGB3 (0.48) | HRH3SMN1; SMN2ITGB3ITGA2BGAA | |
| SCHEMBL8633583 | 0.76 | ITGB3 (0.47) | HRH3HRH1HRH2MAPTNPC1 | |
| SCHEMBL8635829 | 0.75 | MAPT (0.57) | HRH3HRH1HRH2MAPTNPC1 | |
| SCHEMBL8696501 | 0.75 | CYP2C9 (0.49) | HRH3HRH1HRH2MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5753659-A | ANTICOAGULANTS FOR BLOOD DISORDER, CARDIOVASCULAR DISORDER, THROMBOSIS, | ZENECA LIMITED (GB) | 1998-05-19 | — | — | US | disclosed |
| US-5750754-A | TERTIARY BUTYL 3-METHYL-4-SUBSTITUTED BUTYRATE; CHEMICAL INTERMEDIATES FOR ANTICAOGULANT DRUGS | ZENECA LIMITED (GB) | 1998-05-12 | — | — | US | disclosed |
| US-5728701-A | INHIBIT PLATELET AGGREGATION | ZENECA LIMITED (GB) | 1998-03-17 | — | — | US | disclosed |