SCHEMBL8635826

SCHEMBL8635826

O=C(O)C(CCOc1ccccc1)N1CCN(c2ccncc2)CC1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 12/20 0.54
HRH1 P35367 6/20 0.53
HRH2 P25021 2/20 0.53
ITGB3 P05106 1/20 0.49
ITGA2B P08514 1/20 0.49
NPC1 O15118 2/20 0.48
MAPT P10636 2/20 0.48
SMN1; SMN2 Q16637 2/20 0.48
RAB9A P51151 1/20 0.48
PPARG P37231 2/20 0.47
PPARA Q07869 1/20 0.47
KDM4E B2RXH2 1/20 0.46
GAA P10253 1/20 0.46
ALDH1A1 P00352 1/20 0.45
CYP2D6 P10635 1/20 0.45
CYP2C9 P11712 1/20 0.45
TSHR P16473 1/20 0.45
MAPK1 P28482 1/20 0.45
HIF1A Q16665 1/20 0.45
HTR1A P08908 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8681084 0.99 HRH3 (0.53) HRH3HRH1HRH2ITGB3ITGA2B
SCHEMBL8630600 0.94 HRH3 (0.55) HRH3HRH1HRH2ITGB3ITGA2B
SCHEMBL8634522 0.83 HRH3 (0.47) HRH3HRH1HRH2ITGB3ITGA2B
Hydrochloric Acid SCHEMBL8837964 0.79 ITGB3 (0.45) HRH3ITGB3ITGA2BCYP2C9TSHR
SCHEMBL8633583 0.79 ITGB3 (0.47) HRH3HRH1HRH2ITGB3ITGA2B
SCHEMBL8634143 0.77 SLC2A1 (0.47) ITGB3ITGA2BNPC1MAPTSMN1; SMN2
SCHEMBL8635011 0.77 ITGB3 (0.48) HRH3ITGB3ITGA2BSMN1; SMN2GAA
SCHEMBL7403779 0.76 ITGB3 (0.58) HRH3HRH1HRH2ITGB3ITGA2B
SCHEMBL8696501 0.76 CYP2C9 (0.49) HRH3HRH1HRH2ITGB3ITGA2B
Hydrochloric Acid SCHEMBL8837973 0.76 ITGB3 (0.47) HRH3ITGB3ITGA2BGAAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5728701-A INHIBIT PLATELET AGGREGATION ZENECA LIMITED (GB) 1998-03-17 US claimed
US-5753659-A ANTICOAGULANTS FOR BLOOD DISORDER, CARDIOVASCULAR DISORDER, THROMBOSIS, ZENECA LIMITED (GB) 1998-05-19 US disclosed
US-5750754-A TERTIARY BUTYL 3-METHYL-4-SUBSTITUTED BUTYRATE; CHEMICAL INTERMEDIATES FOR ANTICAOGULANT DRUGS ZENECA LIMITED (GB) 1998-05-12 US disclosed
US-5728701-A INHIBIT PLATELET AGGREGATION ZENECA LIMITED (GB) 1998-03-17 US disclosed