Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PLA2G10 | O15496 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CTSV | O60911 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8634456 | 0.84 | MAPT (0.41) | NPC1RAB9AALDH1A1MAPTGAA | |
| SCHEMBL8628998 | 0.83 | MAPT (0.43) | NPC1RAB9AALDH1A1MAPTL3MBTL1 | |
| SCHEMBL8587274 | 0.75 | CCNB2 (0.33) | NPC1RAB9AALDH1A1MAPTGAA | |
| SCHEMBL17367390 | 0.72 | PLA2G10 (0.49) | NPC1RAB9AALDH1A1MAPTGAA | |
| SCHEMBL11848005 | 0.72 | ALDH1A1 (0.44) | NPC1RAB9AALDH1A1MAPTGAA | |
| SCHEMBL2996683 | 0.72 | ALDH1A1 (0.44) | NPC1RAB9AALDH1A1MAPTGAA | |
| SCHEMBL8630712 | 0.71 | NAMPT (0.47) | NPC1RAB9AALDH1A1MAPTGAA | |
| SCHEMBL8636004 | 0.70 | ALDH1A1 (0.49) | NPC1RAB9AALDH1A1MAPTLMNA | |
| SCHEMBL15296667 | 0.70 | NPC1 (0.40) | NPC1RAB9APLA2G10 | |
| SCHEMBL248005 | 0.70 | SMN1; SMN2 (0.43) | NPC1RAB9AALDH1A1MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5840917-A | ADMINISTERING TO MAMMAL TO ERADICATE HELICOBACTER PYLORI | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-11-24 | — | — | US | disclosed |
| EP-0852498-A1 | PHOSPHORYLAMIDES, THEIR PREPARATION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1998-07-15 | — | — | EP | disclosed |
| WO-1997011705-A1 | PHOSPHORYLAMIDES, THEIR PREPARATION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-04-03 | — | — | WO | disclosed |