Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 2/20 | 0.33 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8627681 | 0.80 | NAMPT (0.36) | KDM4EALDH1A1CYP1A2HPGDHSD17B10 | |
| SCHEMBL8623194 | 0.80 | TDP1 (0.44) | KDM4EALDH1A1CYP1A2HPGDHSD17B10 | |
| SCHEMBL8628280 | 0.77 | HTR1A (0.35) | KDM4EALDH1A1CYP1A2HPGDHSD17B10 | |
| SCHEMBL21416125 | 0.77 | ALDH1A1 (0.62) | KDM4EALDH1A1CYP1A2HPGDHSD17B10 | |
| SCHEMBL8625238 | 0.76 | TDP1 (0.36) | KDM4EALDH1A1CYP1A2HPGDHSD17B10 | |
| SCHEMBL8625940 | 0.76 | NAMPT (0.36) | KDM4EALDH1A1CYP1A2HPGDHSD17B10 | |
| SCHEMBL8624536 | 0.73 | SPR (0.36) | CYP1A2NAMPT | |
| SCHEMBL8557791 | 0.71 | GRIA1 (0.34) | — | |
| SCHEMBL25059407 | 0.70 | ADORA3 (0.35) | KDM4EALDH1A1HSD17B10 | |
| SCHEMBL21416213 | 0.70 | ALDH1A1 (1.00) | KDM4EALDH1A1CYP1A2HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618209-B1 | Pyridothiadiazines, processes for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1998-12-23 | — | — | EP | disclosed |
| US-5459138-A | Dysfunctions of glutamatergic neurotransmission associated with learning and memory | ADIR ET COMPAGNIE (FR) | 1995-10-17 | — | — | US | disclosed |
| EP-0618209-A1 | Pyridothiadiazines, processes for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1994-10-05 | — | — | EP | disclosed |