Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 7/20 | 0.35 |
| ▸ | HTR1B | P28222 | 7/20 | 0.35 |
| ▸ | DRD2 | P14416 | 4/20 | 0.35 |
| ▸ | HTR1A | P08908 | 5/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8631771 | 0.83 | FYN (0.43) | HTR1DHTR1BHTR1A | |
| SCHEMBL8628458 | 0.73 | HTR1A (0.64) | HTR1DHTR1BDRD2HTR1A | |
| SCHEMBL8631978 | 0.73 | HTR1A (0.53) | HTR1DHTR1BDRD2HTR1A | |
| SCHEMBL8629596 | 0.72 | HTR1A (0.52) | HTR1DHTR1BDRD2HTR1A | |
| Hydrochloric Acid SCHEMBL8632206 | 0.70 | LMNA (0.37) | HTR1DHTR1BDRD2HTR1AOPRM1 | |
| SCHEMBL8629769 | 0.70 | HTR1A (0.50) | HTR1DHTR1BDRD2HTR1A | |
| SCHEMBL8633421 | 0.70 | HTR1A (0.51) | HTR1DHTR1BDRD2HTR1A | |
| SCHEMBL8631076 | 0.68 | DRD2 (0.36) | DRD2HTR1AOPRM1 | |
| SCHEMBL8627569 | 0.68 | HTR1D (0.51) | HTR1DHTR1BDRD2HTR1A | |
| SCHEMBL8631158 | 0.68 | DRD2 (0.46) | HTR1DHTR1BDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0683155-B1 | Tetrahydrobenz cd indoles with serotonin regulatory activity | LILLY CO ELI (US) | 1998-07-01 | — | — | EP | disclosed |
| EP-0683155-A1 | Tetrahydrobenz cd indoles with serotonin regulatory activity | ELI LILLY AND COMPANY (US) | 1995-11-22 | — | — | EP | disclosed |
| US-5385928-A | Antiserotonine agent | ELI LILLY AND COMPANY (US) | 1995-01-31 | — | — | US | disclosed |