Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.36 |
| ▸ | DRD1 | P21728 | 3/20 | 0.36 |
| ▸ | HTR1A | P08908 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8317710 | 0.88 | VCAM1 (0.37) | DRD2DRD1HTR1AOPRM1 | |
| Hydrochloric Acid SCHEMBL8632206 | 0.81 | LMNA (0.37) | DRD2HTR1ACYP1A2CYP2D6PKM | |
| SCHEMBL8311336 | 0.80 | HTR2A (0.43) | DRD2HTR1ACYP1A2CYP2D6TSHR | |
| SCHEMBL8633421 | 0.77 | HTR1A (0.51) | DRD2HTR1ACYP1A2CYP2D6TSHR | |
| SCHEMBL8634119 | 0.76 | DRD2 (0.34) | DRD2HTR1ACYP1A2CYP2D6PKM | |
| SCHEMBL7445601 | 0.76 | DRD2 (0.42) | DRD2DRD1HTR1A | |
| SCHEMBL8318446 | 0.71 | HTR1A (0.48) | DRD2DRD1HTR1ACYP1A2CYP2D6 | |
| SCHEMBL12640603 | 0.71 | HTR1A (0.43) | DRD2HTR1ACYP1A2CYP2D6TSHR | |
| SCHEMBL10639140 | 0.69 | DRD2 (0.58) | DRD2HTR1A | |
| SCHEMBL7433347 | 0.68 | PNMT (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0683155-B1 | Tetrahydrobenz cd indoles with serotonin regulatory activity | LILLY CO ELI (US) | 1998-07-01 | — | — | EP | disclosed |
| EP-0683155-A1 | Tetrahydrobenz cd indoles with serotonin regulatory activity | ELI LILLY AND COMPANY (US) | 1995-11-22 | — | — | EP | disclosed |