Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TDP2 | O95551 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | UBE2I | P63279 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.42 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8627799 | 0.93 | PTGS2 (0.49) | PTGS2SMN1; SMN2KMT2AMAPTMEN1 | |
| SCHEMBL8629864 | 0.92 | PTGS2 (0.42) | PTGS2SMN1; SMN2TDP2POLBHSP90AA1 | |
| SCHEMBL8631550 | 0.91 | PTGS2 (0.58) | PTGS2POLBKMT2AMAPTMEN1 | |
| SCHEMBL8629761 | 0.90 | PTGS2 (0.48) | PTGS2POLBKMT2AMAPTMEN1 | |
| SCHEMBL8635116 | 0.89 | PTGS2 (0.48) | PTGS2SMN1; SMN2POLBKMT2AMAPT | |
| SCHEMBL8634392 | 0.89 | PTGS2 (0.48) | PTGS2SMN1; SMN2POLBHPGDKMT2A | |
| SCHEMBL8628753 | 0.88 | PTGS2 (0.46) | PTGS2SMN1; SMN2TDP2POLBHSP90AA1 | |
| SCHEMBL8630021 | 0.88 | SMN1; SMN2 (0.49) | PTGS2SMN1; SMN2HPGDKMT2AMAPT | |
| SCHEMBL8634434 | 0.86 | SMN1; SMN2 (0.45) | SMN1; SMN2TDP2POLBHSP90AA1HPGD | |
| SCHEMBL8631097 | 0.86 | PTGS2 (0.43) | PTGS2SMN1; SMN2TDP2POLBHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |