Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.49 |
| ▸ | EDNRB | P24530 | 1/20 | 0.41 |
| ▸ | EDNRA | P25101 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8631550 | 0.94 | PTGS2 (0.58) | PTGS2EDNRBEDNRAMEN1KMT2A | |
| SCHEMBL8629761 | 0.93 | PTGS2 (0.48) | PTGS2EDNRBEDNRAMEN1KMT2A | |
| SCHEMBL8631337 | 0.93 | PTGS2 (0.50) | PTGS2EDNRBEDNRAMEN1KMT2A | |
| SCHEMBL8635116 | 0.90 | PTGS2 (0.48) | PTGS2MEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL8634392 | 0.90 | PTGS2 (0.48) | PTGS2EDNRBEDNRAMEN1KMT2A | |
| SCHEMBL8631097 | 0.86 | PTGS2 (0.43) | PTGS2MEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL8628753 | 0.86 | PTGS2 (0.46) | PTGS2MEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL8632875 | 0.85 | SMN1; SMN2 (0.50) | PTGS2EDNRBEDNRAMEN1KMT2A | |
| SCHEMBL8629864 | 0.85 | PTGS2 (0.42) | PTGS2EDNRAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL8631151 | 0.85 | MEN1 (0.41) | PTGS2EDNRBEDNRAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |