Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.41 |
| ▸ | TTK | P33981 | 2/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8632216 | 0.86 | SCN9A (0.46) | MAPTMEN1KMT2ALMNAF10 | |
| SCHEMBL7780635 | 0.84 | CA2 (0.61) | CA2CA9CA12CA1CA7 | |
| SCHEMBL8632840 | 0.84 | LRRK2 (0.42) | CA2CA9CA12CA1PTGS2 | |
| SCHEMBL8632289 | 0.83 | AKR1B1 (0.40) | TRPV1CA2CA9CA12CA1 | |
| SCHEMBL8632961 | 0.82 | F10 (0.40) | CA2CA9CA12CA1CA7 | |
| SCHEMBL8628206 | 0.81 | PTGES2 (0.39) | CA2CA9CA12CA1PTGS2 | |
| SCHEMBL8631181 | 0.81 | PTGS2 (0.50) | TRPV1CA9PTGS2PTGS1 | |
| SCHEMBL8634768 | 0.81 | F10 (0.42) | CA2CA9CA12CA1F10 | |
| SCHEMBL8627977 | 0.81 | PTGS2 (0.50) | CA2CA9CA12CA1PTGS2 | |
| SCHEMBL8631562 | 0.81 | TRPV1 (0.50) | TRPV1CA2CA1PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |