Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 6/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | GHSR | Q92847 | 1/20 | 0.38 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8634271 | 0.89 | PTGS2 (0.41) | ACLYPTGS2PTGS1PI4KBALDH1A1 | |
| SCHEMBL8629938 | 0.89 | ACLY (0.41) | ACLYSCN9APTGS2PTGS1KDM1A | |
| SCHEMBL8629870 | 0.88 | NPC1 (0.39) | ACLYSCN9APTGS2PTGS1KDM1A | |
| SCHEMBL8629945 | 0.88 | ACLY (0.43) | ACLYSCN9APTGS2PTGS1KDM1A | |
| SCHEMBL8632910 | 0.88 | CCR4 (0.42) | PTGS2PTGS1PI4KB | |
| SCHEMBL8630165 | 0.86 | ACLY (0.39) | ACLYSCN9APTGS2PTGS1KDM1A | |
| SCHEMBL8631722 | 0.86 | PPARA (0.41) | ACLYSCN9APTGS2PTGS1PI4KB | |
| SCHEMBL8628869 | 0.86 | PTGS2 (0.38) | ACLYPTGS2PTGS1PI4KBKDM4E | |
| SCHEMBL8632918 | 0.86 | PI4KB (0.41) | ACLYPTGS2PTGS1PI4KBMAPT | |
| SCHEMBL8631693 | 0.82 | MAPT (0.40) | KDM4EALDH1A1LMNAMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |