Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | KIF11 | P52732 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | MDH2 | P40926 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8541623 | 0.86 | KIF11 (0.43) | MEN1KMT2AATML3MBTL1MAPT | |
| SCHEMBL8632161 | 0.84 | MAPT (0.55) | MEN1KMT2AATML3MBTL1ALDH1A1 | |
| SCHEMBL9165501 | 0.83 | PARP1 (0.41) | KDM4EALDH1A1HSD17B10HPGDMAPT | |
| SCHEMBL8632170 | 0.81 | MAPT (0.64) | KMT2AL3MBTL1KDM4EALDH1A1GAA | |
| SCHEMBL9169051 | 0.80 | ALDH1A1 (0.47) | MEN1KMT2AL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL9164367 | 0.80 | KDM4E (0.45) | KDM4EALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL7338067 | 0.80 | MAPT (0.53) | MEN1KMT2AATML3MBTL1GAA | |
| SCHEMBL9052175 | 0.78 | MAPT (0.59) | MEN1KMT2AKDM4EALDH1A1HSD17B10 | |
| SCHEMBL8540141 | 0.78 | PARP1 (0.43) | MAPTGSK3B | |
| SCHEMBL8538920 | 0.77 | PARP1 (0.45) | MAPTGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0497150-B1 | Angiotensin II receptor blocking 2,3,6-substituted quinazolones | AMERICAN CYANAMID CO (US) | 1998-03-18 | — | — | EP | disclosed |
| CN-1037440-C | Angiotensin II Receptor blocking 2,3,6 substituted quinazolinones | AMERICAL CYANAMID CO (US) | 1998-02-18 | — | — | CN | disclosed |
| US-5405849-A | Treating hypertension, congestive heart failure | AMERICAN CYANAMID COMPANY (US) | 1995-04-11 | — | — | US | disclosed |
| EP-0621276-A1 | Angiotensin II receptor blocking 2,3,6-substituted quinazolinones | AMERICAN CYANAMID COMPANY (US) | 1994-10-26 | — | — | EP | disclosed |
| US-5358951-A | Treating hypertension, congestive heart failure | AMERICAN CYANAMID COMPANY (US) | 1994-10-25 | — | — | US | disclosed |
| US-5294611-A | Hypotensive, congestive heart failure | AMERICAN CYANAMID COMPANY (US) | 1994-03-15 | — | — | US | disclosed |
| US-5292734-A | Angiotensin II receptor blocking 2,3,6 substituted quinazolinones | AMERICAN CYANAMID COMPANY (US) | 1994-03-08 | — | — | US | disclosed |
| US-5290780-A | Hypotensive agents; congestive heart failure | AMERICAN CYANAMID CO. (US) | 1994-03-01 | — | — | US | disclosed |
| US-5286729-A | Therapy for congestive heart failure | AMERICAN CYANAMID COMPANY (US) | 1994-02-15 | — | — | US | disclosed |
| US-5284852-A | Hypotensive agents | AMERICAN CYANAMID COMPANY (US) | 1994-02-08 | — | — | US | disclosed |
| CN-1066847-A | Angiotensin-ii receptor blockers 2,3,6 quinazolinones that replace | AMERICAN CYANAMID CO (US) | 1992-12-09 | — | — | CN | disclosed |
| EP-0497150-A1 | Angiotensin II receptor blocking 2,3,6-substituted quinazolones | AMERICAN CYANAMID COMPANY (US) | 1992-08-05 | — | — | EP | disclosed |